UNIGE document Scientific Article
previous document  unige:97067  next document
add to browser collection
Title

ER-mitochondria contacts control surface glycan expression and sensitivity to killer lymphocytes in glioma stem-like cells

Authors
Pellegatta, Serena
show hidden authors show all authors [1 - 14]
Published in EMBO Journal. 2017, vol. 36, no. 11, p. 1493-1512
Abstract Glioblastoma is a highly heterogeneous aggressive primary brain tumor, with the glioma stem-like cells (GSC) being more sensitive to cytotoxic lymphocyte-mediated killing than glioma differentiated cells (GDC). However, the mechanism behind this higher sensitivity is unclear. Here, we found that the mitochondrial morphology of GSCs modulates the ER-mitochondria contacts that regulate the surface expression of sialylated glycans and their recognition by cytotoxic T lymphocytes and natural killer cells. GSCs displayed diminished ER-mitochondria contacts compared to GDCs. Forced ER-mitochondria contacts in GSCs increased their cell surface expression of sialylated glycans and reduced their susceptibility to cytotoxic lymphocytes. Therefore, mitochondrial morphology and dynamism dictate the ER-mitochondria contacts in order to regulate the surface expression of certain glycans and thus play a role in GSC recognition and elimination by immune effector cells. Targeting the mitochondrial morphology, dynamism, and contacts with the ER could be an innovative strategy to deplete the cancer stem cell compartment to successfully treat glioblastoma.
Keywords AnimalsCell LineEndoplasmic Reticulum/metabolismHumansKiller Cells, Natural/immunologyMiceMitochondria/metabolismNeuroglia/physiologyPolysaccharides/biosynthesisStem Cells/physiologyT-Lymphocytes, Cytotoxic/immunology
Identifiers
PMID: 28283580
Full text
Article (Published version) (6.6 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Research groups Immunothérapie des cancers (42)
Immunobiologie des tumeurs du cerveau (669)
Citation
(ISO format)
BASSOY, Esen et al. ER-mitochondria contacts control surface glycan expression and sensitivity to killer lymphocytes in glioma stem-like cells. In: EMBO Journal, 2017, vol. 36, n° 11, p. 1493-1512. https://archive-ouverte.unige.ch/unige:97067

175 hits

7 downloads

Update

Deposited on : 2017-09-27

Export document
Format :
Citation style :