No age effect in the prevalence and clinical significance of ultra-high risk symptoms and criteria for psychosis in 22q11 deletion syndrome: Confirmation of the genetically driven risk for psychosis?

Armando, Marco; Schneider, Maude; Pontillo, Maria; Vicari, Stefano; Debbané, Martin; Schultze-Lutter, Frauke; Eliez, Stéphan

doi:10.1371/journal.pone.0174797

Scientific article

English

No age effect in the prevalence and clinical significance of ultra-high risk symptoms and criteria for psychosis in 22q11 deletion syndrome: Confirmation of the genetically driven risk for psychosis?

ContributorsArmando, Marco; Schneider, Maude; Pontillo, Maria; Vicari, Stefano; Debbané, Martin; Schultze-Lutter, Frauke; Eliez, Stéphan

Published inPLOS ONE, vol. 12, no. 4, e0174797

Publication date2017

Abstract

The 22q11.2 deletion syndrome (22q11DS) is one of the highest known risk factors for schizophrenia. Thus, the detection of 22q11DS patients at particularly high risk of psychosis is important, yet studies on the clinical significance of the widely used ultra-high risk (UHR) criteria in 22q11DS are inconclusive. Since age was reported to moderate clinical significance of UHR symptoms in community samples, we explored whether age at presentation of UHR symptoms and criteria may explain part of this heterogeneity.

Keywords

22q11 Deletion Syndrome/genetics/physiopathology/psychology
Adolescent
Adult
Age Factors
Age of Onset
Child
Female
Humans
Male
Psychotic Disorders/genetics/physiopathology/psychology
Schizophrenia/genetics/physiopathology

Affiliation entities

Research groups

Laboratoire d'imagerie et de psychopathologie développementale (693)

Citation (ISO format)

ARMANDO, Marco et al. No age effect in the prevalence and clinical significance of ultra-high risk symptoms and criteria for psychosis in 22q11 deletion syndrome: Confirmation of the genetically driven risk for psychosis? In: PLOS ONE, 2017, vol. 12, n° 4, p. e0174797. doi: 10.1371/journal.pone.0174797