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Title

No age effect in the prevalence and clinical significance of ultra-high risk symptoms and criteria for psychosis in 22q11 deletion syndrome: Confirmation of the genetically driven risk for psychosis?

Authors
Pontillo, Maria
Vicari, Stefano
Schultze-Lutter, Frauke
Published in PLOS ONE. 2017, vol. 12, no. 4, p. e0174797
Abstract The 22q11.2 deletion syndrome (22q11DS) is one of the highest known risk factors for schizophrenia. Thus, the detection of 22q11DS patients at particularly high risk of psychosis is important, yet studies on the clinical significance of the widely used ultra-high risk (UHR) criteria in 22q11DS are inconclusive. Since age was reported to moderate clinical significance of UHR symptoms in community samples, we explored whether age at presentation of UHR symptoms and criteria may explain part of this heterogeneity.
Keywords 22q11 Deletion Syndrome/genetics/physiopathology/psychologyAdolescentAdultAge FactorsAge of OnsetChildFemaleHumansMalePsychotic Disorders/genetics/physiopathology/psychologySchizophrenia/genetics/physiopathology
Identifiers
PMID: 28406913
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Research group Laboratoire d'imagerie et de psychopathologie développementale (693)
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ARMANDO, Marco et al. No age effect in the prevalence and clinical significance of ultra-high risk symptoms and criteria for psychosis in 22q11 deletion syndrome: Confirmation of the genetically driven risk for psychosis?. In: PLOS ONE, 2017, vol. 12, n° 4, p. e0174797. https://archive-ouverte.unige.ch/unige:97042

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Deposited on : 2017-09-26

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