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Scientific article
English

Evolution of immune chemoreceptors into sensors of the outside world

Publication date2017
Abstract

Immune formyl peptide receptors (Fprs) evolved in rodents from expression in immune cells to be transcribed in olfactory sensory neurons. Explaining the initial neuronal acquisition, we found that an Fpr coding exon landed in front of a vomeronasal receptor promoter, hijacking its expression pattern. This type of gene shuffling occurred twice in the mouse lineage, many million years apart, leading to the exclusive expression of Fprs in the two main populations of vomeronasal sensory neurons. Finally, we demonstrate that the immune expression of one of the mouse vomeronasal Fprs can be restored via the production of an intergenic transcript. Thus, we provide the complete history of genomic events that led to a model case of evolutionary neofunctionalization in a mammal.

Keywords
  • Evolution
  • Chemosensor
  • Neofunctionalization
  • Rodent
  • Formyl peptide receptor
Citation (ISO format)
DIETSCHI, Quentin et al. Evolution of immune chemoreceptors into sensors of the outside world. In: Proceedings of the National Academy of Sciences of the United States of America, 2017, vol. 14, n° 28, p. 7397–7402. doi: 10.1073/pnas.1704009114
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0027-8424
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Technical informations

Creation07/06/2017 10:33:00 AM
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