Evolution of immune chemoreceptors into sensors of the outside world

Article Article scientifique Article Evolution of immune chemoreceptors into sensors of the outside world eng 2017 author Dietschi Quentin 632833 author Tuberosa Joël 0000-0001-6022-0556 644501 author Roesingh Lone Neelchen 777664 author Loichot Gregory 560430 author Rüedi Manuel 815550 author Carleton Alan 676577 author Rodriguez Ivan 28183 7397-7402 10.1073/pnas.1704009114 0027-8424 Immune formyl peptide receptors (Fprs) evolved in rodents from expression in immune cells to be transcribed in olfactory sensory neurons. Explaining the initial neuronal acquisition, we found that an Fpr coding exon landed in front of a vomeronasal receptor promoter, hijacking its expression pattern. This type of gene shuffling occurred twice in the mouse lineage, many million years apart, leading to the exclusive expression of Fprs in the two main populations of vomeronasal sensory neurons. Finally, we demonstrate that the immune expression of one of the mouse vomeronasal Fprs can be restored via the production of an intergenic transcript. Thus, we provide the complete history of genomic events that led to a model case of evolutionary neofunctionalization in a mammal. Evolution Chemosensor Neofunctionalization Rodent Formyl peptide receptor Dewey 590 Dewey 616.8 Swiss National Science Foundation Sick conspecific avoidance - molecules, vomeronasal receptors and neural circuits 170114 CH Project funding Swiss National Science Foundation A novel olfactory sensory population 143723 CH Project funding 16 Centre interfacultaire de neurosciences 0D9 44 Département de génétique et évolution 162 53 Département de neurosciences fondamentales 21A false 536 Groupe Carleton Alan (neurosciences fondamentales) 876 820 Groupe Rodriguez Proceedings of the National Academy of Sciences of the United States of America 14 28 b4469221-18e7-4c4d-8a05-e2039cfa6b94 Article (Published version) Restricted dietschiPNAS2017.pdf 1559654 application/pdf restrictedAccess Centres et instituts / Centre interfacultaire de neurosciences Faculté des sciences / Section de biologie / Département de génétique et évolution Faculté de médecine / Section de médecine fondamentale / Département de neurosciences fondamentales

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Evolution of immune chemoreceptors into sensors of the outside world	Proceedings of the National Academy of Sciences of the United States of America			2017	598	8

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Roesingh, Lone Neelchen