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Title

UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal Extracts

Authors
Gindro, Katia
Published in Phytochemical Analysis. 2017, vol. 28, no. 2, p. 93-100
Abstract Histone deacetylases (HDAC) are considered as promising targets for cancer treatment. Today, four HDAC inhibitors, vorinostat, romidepsin, belinostat, and panobinostat, have been approved by the Food and Drug Administration (FDA) for cancer treatment, while others are in clinical trials. Among them, several are naturally occurring fungal metabolites.
Keywords ChromatographyHigh Pressure Liquid/methodsFungi/metabolismHistone Deacetylases/metabolismTandem Mass Spectrometry/methods
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PMID: 27921344
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ZWICK, Vincent et al. UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal Extracts. In: Phytochemical Analysis, 2017, vol. 28, n° 2, p. 93-100. https://archive-ouverte.unige.ch/unige:94971

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Deposited on : 2017-06-20

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