UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal Extracts

Zwick, Vincent; Allard, Pierre-Marie; Ory, Lucie; Simoes Avello, Claudia; Marcourt, Laurence; Gindro, Katia; Wolfender, Jean-Luc; Cuendet, Muriel

doi:10.1002/pca.2652

Scientific article

English

UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal Extracts

ContributorsZwick, Vincent; Allard, Pierre-Marie; Ory, Lucie; Simoes Avello, Claudia; Marcourt, Laurence; Gindro, Katia; Wolfender, Jean-Luc; Cuendet, Muriel

Published inPhytochemical analysis, vol. 28, no. 2, p. 93-100

Publication date2017

Abstract

Histone deacetylases (HDAC) are considered as promising targets for cancer treatment. Today, four HDAC inhibitors, vorinostat, romidepsin, belinostat, and panobinostat, have been approved by the Food and Drug Administration (FDA) for cancer treatment, while others are in clinical trials. Among them, several are naturally occurring fungal metabolites.

Keywords

Chromatography
High Pressure Liquid/methods
Fungi/metabolism
Histone Deacetylases/metabolism
Tandem Mass Spectrometry/methods

Affiliation entities

Faculté des sciences / Section des sciences pharmaceutiques

Research groups

Phytochimie et produits naturels bioactifs

Citation (ISO format)

ZWICK, Vincent et al. UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal Extracts. In: Phytochemical analysis, 2017, vol. 28, n° 2, p. 93–100. doi: 10.1002/pca.2652

Article (Published version)

Identifiers

PID : unige:94971
DOI : 10.1002/pca.2652
PMID : 27921344

Journal ISSN0958-0344

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Creation14/06/2017 01:04:00

First validation14/06/2017 01:04:00

Update time15/03/2023 02:47:28

Status update15/03/2023 02:47:27

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UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal Extracts

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