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UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal Extracts

Publié dansPhytochemical analysis, vol. 28, no. 2, p. 93-100
Date de publication2017
Résumé

Histone deacetylases (HDAC) are considered as promising targets for cancer treatment. Today, four HDAC inhibitors, vorinostat, romidepsin, belinostat, and panobinostat, have been approved by the Food and Drug Administration (FDA) for cancer treatment, while others are in clinical trials. Among them, several are naturally occurring fungal metabolites.

Mots-clés
  • Chromatography
  • High Pressure Liquid/methods
  • Fungi/metabolism
  • Histone Deacetylases/metabolism
  • Tandem Mass Spectrometry/methods
Citation (format ISO)
ZWICK, Vincent et al. UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal Extracts. In: Phytochemical analysis, 2017, vol. 28, n° 2, p. 93–100. doi: 10.1002/pca.2652
Fichiers principaux (1)
Article (Published version)
accessLevelRestricted
Identifiants
ISSN du journal0958-0344
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Informations techniques

Création13/06/2017 23:04:00
Première validation13/06/2017 23:04:00
Heure de mise à jour15/03/2023 01:47:28
Changement de statut15/03/2023 01:47:27
Dernière indexation02/05/2024 19:23:13
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