UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal Extracts

Article Article scientifique Article UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal Extracts eng 2017 author Zwick Vincent 595034 author Allard Pierre-Marie 812151 author Ory Lucie 831942 author Simoes Avello Claudia 630402 author Marcourt Laurence 729234 author Gindro Katia author Wolfender Jean-Luc 135649 author Cuendet Muriel 0000-0002-1523-1907 686755 93-100 10.1002/pca.2652 27921344 0958-0344 Histone deacetylases (HDAC) are considered as promising targets for cancer treatment. Today, four HDAC inhibitors, vorinostat, romidepsin, belinostat, and panobinostat, have been approved by the Food and Drug Administration (FDA) for cancer treatment, while others are in clinical trials. Among them, several are naturally occurring fungal metabolites. Chromatography High Pressure Liquid/methods Fungi/metabolism Histone Deacetylases/metabolism Tandem Mass Spectrometry/methods Dewey 615 31 Section des sciences pharmaceutiques 17 false 882 Phytochimie et produits naturels bioactifs Phytochemical analysis 28 2 8cc50a45-1254-4bf8-acbc-ba91756047d9 Article (Published version) Restricted Zwick et al Phytochem Anal 2016.pdf 425019 application/pdf restrictedAccess Faculté des sciences / Section des sciences pharmaceutiques

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UHPLC-MS-based HDAC Assay Applied to Bio-guided Microfractionation of Fungal Extracts	Phytochemical analysis			2017	521	3

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Ory, Lucie