Antifungals and acetylcholinesterase inhibitors from the stem bark of Croton heliotropiifolius

Ferreira Queiroz, Marcos Marcal; Ferreira Queiroz, Emerson; Zeraik, Maria Luiza; Marti, Guillaume; Favre-Godal, Quentin; Simoes Avello, Claudia; Marcourt, Laurence; Carrupt, Pierre-Alain; Cuendet Licea, Muriel; Paulo, M.Q.; Bolzani, V.S.; Wolfender, Jean-Luc

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Title		Antifungals and acetylcholinesterase inhibitors from the stem bark of Croton heliotropiifolius
Authors		Ferreira Queiroz, Marcos Marcal Ferreira Queiroz, Emerson Zeraik, Maria Luiza Marti, Guillaume Favre-Godal, Quentin Simoes Avello, Claudia Marcourt, Laurence Carrupt, Pierre-Alain Cuendet Licea, Muriel Paulo, M.Q. Bolzani, V.S. Wolfender, Jean-Luc show all authors [1 - 12]
Published in		Phytochemistry Letters. 2014, vol. 10, p. lxxxviii-xciii
Abstract		The ethanolic extract of the stem bark of Croton heliotropiifolius Kunth (Euphorbiaceae) showed significant in vitro inhibition of acetylcholinesterase using a dilution spectrophotometric assay and antifungal activity against Candida albicans with a thin layer chromatography (TLC) bioautographic assay. In order to isolate the active compounds, bioassay-guided fractionation was undertaken using HPLC to localize the active compounds. Different zones of the HPLC-UV chromatogram were linked to acetylcholinesterase inhibition or to antifungal activities. In parallel to this HPLC-based activity profiling, HPLC-PDA-ESI-MS and HPLC-TOF-HRMS were used for the early identification of some of the compounds present. The targeted isolation of the active compounds was performed by medium pressure liquid chromatography (MPLC-UV) and further semi-preparative HPLC. Using this approach, nine compounds were isolated, one of them being a new indole alkaloid derivative. The structures of the isolated compounds were elucidated by spectroscopic methods including UV, NMR, MS and HRMS.
Identifiers		DOI: 10.1016/j.phytol.2014.08.013
Full text		Article (Published version) (626 Kb) - Limited access to UNIGE Other version: http://linkinghub.elsevier.com/retrieve/pii/S1874390014001499
Structures		Faculté des sciences / Section des sciences pharmaceutiques
Citation (ISO format)		FERREIRA QUEIROZ, Marcos Marcal et al. Antifungals and acetylcholinesterase inhibitors from the stem bark of Croton heliotropiifolius. In: Phytochemistry Letters, 2014, vol. 10, p. lxxxviii-xciii. https://archive-ouverte.unige.ch/unige:94961