Antifungals and acetylcholinesterase inhibitors from the stem bark of Croton heliotropiifolius

Ferreira Queiroz, Marcos Marcal; Ferreira Queiroz, Emerson; Zeraik, Maria Luiza; Marti, Guillaume; Favre-Godal, Quentin; Simoes Avello, Claudia; Marcourt, Laurence; Carrupt, Pierre-Alain; Cuendet, Muriel; Paulo, M.Q.; Bolzani, V.S.; Wolfender, Jean-Luc

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Title		Antifungals and acetylcholinesterase inhibitors from the stem bark of Croton heliotropiifolius
Authors		Ferreira Queiroz, Marcos Marcal Ferreira Queiroz, Emerson Zeraik, Maria Luiza Marti, Guillaume Favre-Godal, Quentin Simoes Avello, Claudia Marcourt, Laurence Carrupt, Pierre-Alain Cuendet, Muriel Paulo, M.Q. Bolzani, V.S. Wolfender, Jean-Luc show all authors [1 - 12]
Published in		Phytochemistry Letters. 2014, vol. 10, p. lxxxviii-xciii
Abstract		The ethanolic extract of the stem bark of Croton heliotropiifolius Kunth (Euphorbiaceae) showed significant in vitro inhibition of acetylcholinesterase using a dilution spectrophotometric assay and antifungal activity against Candida albicans with a thin layer chromatography (TLC) bioautographic assay. In order to isolate the active compounds, bioassay-guided fractionation was undertaken using HPLC to localize the active compounds. Different zones of the HPLC-UV chromatogram were linked to acetylcholinesterase inhibition or to antifungal activities. In parallel to this HPLC-based activity profiling, HPLC-PDA-ESI-MS and HPLC-TOF-HRMS were used for the early identification of some of the compounds present. The targeted isolation of the active compounds was performed by medium pressure liquid chromatography (MPLC-UV) and further semi-preparative HPLC. Using this approach, nine compounds were isolated, one of them being a new indole alkaloid derivative. The structures of the isolated compounds were elucidated by spectroscopic methods including UV, NMR, MS and HRMS.
Identifiers		DOI: 10.1016/j.phytol.2014.08.013
Full text		Article (Published version) (626 Kb) - Limited access to UNIGE Other version: http://linkinghub.elsevier.com/retrieve/pii/S1874390014001499
Structures		Faculté des sciences / Section des sciences pharmaceutiques
Research group		Phytochimie et produits naturels bioactifs
Citation (ISO format)		FERREIRA QUEIROZ, Marcos Marcal et al. Antifungals and acetylcholinesterase inhibitors from the stem bark of Croton heliotropiifolius. In: Phytochemistry Letters, 2014, vol. 10, p. lxxxviii-xciii. https://archive-ouverte.unige.ch/unige:94961