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Title

Prévalence de la transmission de virus résistant à la zidovudine en Suisse. L'étude suisse de cohorte VIH

Authors
Rakik, A.
Kinloch-de-Loes, S.
Erb, P.
Vernazza, P.
Published in Schweizerische medizinische Wochenschrift. 1996, vol. 126, no. 43, p. 1845-1848
Abstract Zidovudine (ZDV) was the most widely used anti-HIV drug between 1987 and 1995, and, as already reported, transmission of ZDV-resistant viruses occurs. Several mutations of the reverse transcriptase gene have been identified; one of them affects the 215 codon and is associated with a high degree of resistance. We have determined, using selective PCR, the prevalence of transmission of 215 mutant isolates in 134 patients with primary HIV infection (PHI) and have identified 8 patients with 215 mutant virus between 1989 and 1995 in Switzerland. Mutant resistant viruses have been isolated from patients treated with most antiviral drugs. A systematic search for mutant viruses may provide useful information for the adaptation of treatment strategies.
Keywords AdolescentAdultAntiviral Agents/ pharmacologyBase SequenceDNA, Viral/geneticsDrug Resistance/geneticsFemaleHIV/ drug effects/geneticsHIV Infections/ transmissionHIV Reverse Transcriptase/geneticsHumansMaleMiddle AgedMolecular Sequence DataPolymerase Chain ReactionRetrospective StudiesZidovudine/ pharmacology
Identifiers
PMID: 9005525
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YERLY FERRILLO, Sabine et al. Prévalence de la transmission de virus résistant à la zidovudine en Suisse. L'étude suisse de cohorte VIH. In: Schweizerische medizinische Wochenschrift, 1996, vol. 126, n° 43, p. 1845-1848. https://archive-ouverte.unige.ch/unige:9485

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Deposited on : 2010-07-12

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