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Scientific article
English

Early and prolonged decrease of viremia in HIV-1-infected patients treated with didanosine

Publication date1995
Abstract

Fourteen patients previously treated with zidovudine were monitored for laboratory parameters and clinical events during 1 year after introduction of didanosine (ddI) monotherapy. Proviral human immunodeficiency virus type 1 (HIV-1) copy numbers (cell-associated DNA) and concentration of free virions (viremia) were determined using a semiquantitative polymerase chain reaction (PCR). High levels of circulating virus were detected in all patients (range, 17 to 5,934 x 10(3)/ml of serum). Within 4 weeks of therapy, a decrease of viremia (60 to 98%) was observed in nine patients. After 1 year of treatment, eight of these nine patients still had decreased viremia when proviral HIV DNA was decreased or stable, and CD4+ lymphocytes were stable or higher in seven of these eight patients. Antiviral effect was more pronounced in the six patients with CD4+ > 100/mm3 at entry, five of them belonging to the subgroup of the seven responding patients as compared to two of eight patients with CD4+ < 100/mm3. Clinical events in this small group were not statistically correlated with virologic parameters; however, responding patients had a tendency to stabilize or gain weight. This study suggests that measurement of viremia deserves further study as a marker of antiviral efficacy and might predict, even at 4 weeks, the beneficial potential of ddI.

Keywords
  • AIDS-Related Opportunistic Infections/immunology
  • CD4 Lymphocyte Count
  • DNA, Viral/analysis
  • Didanosine/ therapeutic use
  • HIV Core Protein p24/analysis
  • HIV Infections/ drug therapy/virology
  • HIV-1/genetics
  • Humans
  • Polymerase Chain Reaction
  • Proviruses/genetics
  • RNA, Viral/analysis
  • Viremia/ drug therapy/virology
  • Virion/drug effects/genetics
  • Zidovudine/therapeutic use
Citation (ISO format)
YERLY FERRILLO, Sabine et al. Early and prolonged decrease of viremia in HIV-1-infected patients treated with didanosine. In: Journal of acquired immune deficiency syndromes and human retrovirology, 1995, vol. 8, n° 4, p. 358–364.
Identifiers
ISSN of the journal1077-9450
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