Predictive value of codon 215 reverse transcriptase mutation on the efficacy of didanosine in HIV-infected, zidovudine-experienced patients

Yerly Ferrillo, Sabine; Denereaz, N.; Mermillod, Bernadette; Hirschel, Bernard; Perrin, Luc

Scientific article

English

Predictive value of codon 215 reverse transcriptase mutation on the efficacy of didanosine in HIV-infected, zidovudine-experienced patients

Contributors

Yerly Ferrillo, Sabine; Denereaz, N.; Mermillod, Bernadette; Hirschel, Bernard; Perrin, Luc

Published in

Antiviral therapy, vol. 1, no. 3, p. 167-171

Publication date

1996

Abstract

We investigated whether or not mutations at codon 215 in the HIV reverse-transcriptase-encoding gene predicted a lower efficacy of didanosine therapy, as defined by survival of patients and change in CD4 cell counts in 121 HIV-infected, zidovudine-experienced patients. A trend for shorter survival, although not reaching significance, was observed for patients with HIV strains with the reverse transcriptase codon 215 mutation (P = 0.07), but this trend disappeared after adjustment for initial CD4 cell counts. During the first 3 months on didanosine therapy, the increase in CD4 cell counts was greater in patients who were wild type at codon 215 than in those with the mutation at codon 215 (P = 0.03). These data suggest that there was a better initial CD4 response to didanosine therapy in patients with HIV without the mutation at codon 215, but that this response did not translate into increased survival.

Keywords

Anti-HIV Agents/ therapeutic use
CD4 Lymphocyte Count
Codon
Didanosine/ therapeutic use
Female
HIV Infections/ drug therapy/immunology/mortality
HIV Reverse Transcriptase/ genetics
Humans
Male
Mutation
Retrospective Studies
Survival Rate
Zidovudine/ therapeutic use

UNIGE affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement

Citation (ISO format)

YERLY FERRILLO, Sabine et al. Predictive value of codon 215 reverse transcriptase mutation on the efficacy of didanosine in HIV-infected, zidovudine-experienced patients. In: Antiviral therapy, 1996, vol. 1, n° 3, p. 167–171.

Identifiers

PID : unige:9482
PMID : 11322250

Journal ISSN

1359-6535

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Creation

12/07/2010 14:37:24

First validation

12/07/2010 14:37:24

Update

14/03/2023 15:54:49

Status update

14/03/2023 15:54:49

Last indexation

29/10/2024 16:08:59

Predictive value of codon 215 reverse transcriptase mutation on the efficacy of didanosine in HIV-infected, zidovudine-experienced patients

Contributors

Published in

Publication date

Abstract

Keywords

UNIGE affiliation entities

Citation (ISO format)

Identifiers

Journal ISSN

Technical informations

Creation

First validation

Update

Status update

Last indexation