en
Scientific article
English

Inter- and intrahemispheric dissociations in ideomotor apraxia: a large-scale lesion-symptom mapping study in subacute brain-damaged patients

Published inCerebral cortex, vol. 23, no. 12, p. 2781-2789
Publication date2013
Abstract

Pantomimes of object use require accurate representations of movements and a selection of the most task-relevant gestures. Prominent models of praxis, corroborated by functional neuroimaging studies, predict a critical role for left parietal cortices in pantomime and advance that these areas store representations of tool use. In contrast, lesion data points to the involvement of left inferior frontal areas, suggesting that defective selection of movement features is the cause of pantomime errors. We conducted a large-scale voxel-based lesion-symptom mapping analyses with configural/spatial (CS) and body-part-as-object (BPO) pantomime errors of 150 left and right brain-damaged patients. Our results confirm the left hemisphere dominance in pantomime. Both types of error were associated with damage to left inferior frontal regions in tumor and stroke patients. While CS pantomime errors were associated with left temporoparietal lesions in both stroke and tumor patients, these errors appeared less associated with parietal areas in stroke than in tumor patients and less associated with temporal in tumor than stroke patients. BPO errors were associated with left inferior frontal lesions in both tumor and stroke patients. Collectively, our results reveal a left intrahemispheric dissociation for various aspects of pantomime, but with an unspecific role for inferior frontal regions.

Keywords
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Apraxia, Ideomotor/pathology/physiopathology
  • Brain Damage, Chronic/pathology/physiopathology
  • Brain Mapping
  • Cerebral Cortex/pathology/physiopathology
  • Female
  • Frontal Lobe/pathology/physiopathology
  • Functional Laterality
  • Humans
  • Imitative Behavior
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Parietal Lobe/pathology/physiopathology
  • Young Adult
Affiliation Not a UNIGE publication
Citation (ISO format)
MANUEL, Aurélie et al. Inter- and intrahemispheric dissociations in ideomotor apraxia: a large-scale lesion-symptom mapping study in subacute brain-damaged patients. In: Cerebral cortex, 2013, vol. 23, n° 12, p. 2781–2789. doi: 10.1093/cercor/bhs280
Main files (1)
Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal1047-3211
399views
0downloads

Technical informations

Creation05/01/2017 2:25:00 PM
First validation05/01/2017 2:25:00 PM
Update time03/15/2023 1:43:35 AM
Status update03/15/2023 1:43:35 AM
Last indexation01/17/2024 12:01:52 AM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack