Inter- and intrahemispheric dissociations in ideomotor apraxia: a large-scale lesion-symptom mapping study in subacute brain-damaged patients

Article Article scientifique Article Inter- and intrahemispheric dissociations in ideomotor apraxia: a large-scale lesion-symptom mapping study in subacute brain-damaged patients eng 2013 author Manuel Aurélie 796123 Aurélie L. Manuel author Radman Narges 752880 author Mesot Delphine author Chouiter Leila author Clarke Stephanie author Annoni Gian-Maria 133986 author Spierer Lucas 502880 2781-2789 10.1093/cercor/bhs280 22989580 1047-3211 Pantomimes of object use require accurate representations of movements and a selection of the most task-relevant gestures. Prominent models of praxis, corroborated by functional neuroimaging studies, predict a critical role for left parietal cortices in pantomime and advance that these areas store representations of tool use. In contrast, lesion data points to the involvement of left inferior frontal areas, suggesting that defective selection of movement features is the cause of pantomime errors. We conducted a large-scale voxel-based lesion-symptom mapping analyses with configural/spatial (CS) and body-part-as-object (BPO) pantomime errors of 150 left and right brain-damaged patients. Our results confirm the left hemisphere dominance in pantomime. Both types of error were associated with damage to left inferior frontal regions in tumor and stroke patients. While CS pantomime errors were associated with left temporoparietal lesions in both stroke and tumor patients, these errors appeared less associated with parietal areas in stroke than in tumor patients and less associated with temporal in tumor than stroke patients. BPO errors were associated with left inferior frontal lesions in both tumor and stroke patients. Collectively, our results reveal a left intrahemispheric dissociation for various aspects of pantomime, but with an unspecific role for inferior frontal regions. Adolescent Adult Aged Aged, 80 and over Apraxia, Ideomotor/pathology/physiopathology Brain Damage, Chronic/pathology/physiopathology Brain Mapping Cerebral Cortex/pathology/physiopathology Female Frontal Lobe/pathology/physiopathology Functional Laterality Humans Imitative Behavior Magnetic Resonance Imaging Male Middle Aged Parietal Lobe/pathology/physiopathology Young Adult true Cerebral cortex 23 12 c5c5e9b3-810f-47ca-8cf9-3cabb8a0654a Article (Published version) Restricted bhs280.pdf 1298714 application/pdf restrictedAccess

Title	Published in	Year	Views	Downloads

Inter- and intrahemispheric dissociations in ideomotor apraxia: a large-scale lesion-symptom mapping study in subacute brain-damaged patients	Cerebral cortex	2013	475	0
Poststroke fatigue following minor infarcts: a prospective study	Neurology	2012	536	0

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