UNIGE document Scientific Article
previous document  unige:9448  next document
add to browser collection

Didanosine plus stavudine with or without hydroxyurea in HIV-1-infected patients: 1 year follow-up. Swiss HIV Cohort Study

Opravil, M.
Iten, A.
Malinverni, R.
Vernazza, P. L.
Bucher, H.
show hidden authors show all authors [1 - 10]
Published in Antiviral therapy. 1998, vol. 3, no. Suppl 4, p. 65-67
Abstract A total of 144 human immunodeficiency virus (HIV)-infected patients (mean CD4 cell count, 367 cells/mm3) were included in a double-blind placebo-controlled trial testing the efficacy on surrogate markers of HIV progression of the combination didanosine (2',3'-dideoxyinosine or DDI) plus stavudine (2',3'-didehydro-2',3'-dideoxythymidine or D4T) with or without hydroxyurea. The primary end point was a reduction of HIV RNA levels to below 200 copies/ml after 12 weeks of treatment. The results showed that the triple combination was associated with a more profound decrease in HIV RNA with an increased proportion of patients with viraemia < 200 copies/ml. This effect persisted for the majority of the patients after a 48 week follow-up. In contrast, the increase in CD4 cell counts was less in patients treated with hydroxyurea because of lymphopenia, and adverse events were more frequent in hydroxyurea-treated patients. In conclusion, the addition of hydroxyurea consistently improved the antiviral activity of the didanosine/stavudine combination over a 48 week follow-up. Increased toxicity and decreased effect on CD4 cell counts might inspire caution.
Keywords Anti-HIV Agents/adverse effects/therapeutic useCD4 Lymphocyte CountDidanosine/adverse effects/ therapeutic useDrug SynergismDrug Therapy, CombinationFollow-Up StudiesHIV Infections/ drug therapyHiv-1HumansHydroxyurea/adverse effects/ therapeutic useRNA, Viral/bloodReverse Transcriptase Inhibitors/adverse effects/therapeutic useStavudine/adverse effects/ therapeutic use
PMID: 10723515
Full text
This document has no fulltext available yet, but you can contact its author by using the form below.
(ISO format)
RUTSCHMANN, Olivier Thierry et al. Didanosine plus stavudine with or without hydroxyurea in HIV-1-infected patients: 1 year follow-up. Swiss HIV Cohort Study. In: Antiviral therapy, 1998, vol. 3, n° Suppl 4, p. 65-67. https://archive-ouverte.unige.ch/unige:9448

368 hits

0 download


Deposited on : 2010-07-12

Export document
Format :
Citation style :