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Title

Didanosine plus stavudine with or without hydroxyurea in HIV-1-infected patients: 1 year follow-up. Swiss HIV Cohort Study

Authors
Opravil, M.
Iten, A.
Malinverni, R.
Vernazza, P. L.
Bucher, H.
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Published in Antiviral Therapy. 1998, vol. 3, no. Suppl 4, p. 65-67
Abstract A total of 144 human immunodeficiency virus (HIV)-infected patients (mean CD4 cell count, 367 cells/mm3) were included in a double-blind placebo-controlled trial testing the efficacy on surrogate markers of HIV progression of the combination didanosine (2',3'-dideoxyinosine or DDI) plus stavudine (2',3'-didehydro-2',3'-dideoxythymidine or D4T) with or without hydroxyurea. The primary end point was a reduction of HIV RNA levels to below 200 copies/ml after 12 weeks of treatment. The results showed that the triple combination was associated with a more profound decrease in HIV RNA with an increased proportion of patients with viraemia < 200 copies/ml. This effect persisted for the majority of the patients after a 48 week follow-up. In contrast, the increase in CD4 cell counts was less in patients treated with hydroxyurea because of lymphopenia, and adverse events were more frequent in hydroxyurea-treated patients. In conclusion, the addition of hydroxyurea consistently improved the antiviral activity of the didanosine/stavudine combination over a 48 week follow-up. Increased toxicity and decreased effect on CD4 cell counts might inspire caution.
Keywords Anti-HIV Agents/adverse effects/therapeutic useCD4 Lymphocyte CountDidanosine/adverse effects/ therapeutic useDrug SynergismDrug Therapy, CombinationFollow-Up StudiesHIV Infections/ drug therapyHiv-1HumansHydroxyurea/adverse effects/ therapeutic useRNA, Viral/bloodReverse Transcriptase Inhibitors/adverse effects/therapeutic useStavudine/adverse effects/ therapeutic use
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PMID: 10723515
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RUTSCHMANN, Olivier Thierry et al. Didanosine plus stavudine with or without hydroxyurea in HIV-1-infected patients: 1 year follow-up. Swiss HIV Cohort Study. In: Antiviral Therapy, 1998, vol. 3, n° Suppl 4, p. 65-67. https://archive-ouverte.unige.ch/unige:9448

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Deposited on : 2010-07-12

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