en
Scientific article
English

Didanosine plus stavudine with or without hydroxyurea in HIV-1-infected patients: 1 year follow-up. Swiss HIV Cohort Study

Published inAntiviral therapy, vol. 3, no. Suppl 4, p. 65-67
Publication date1998
Abstract

A total of 144 human immunodeficiency virus (HIV)-infected patients (mean CD4 cell count, 367 cells/mm3) were included in a double-blind placebo-controlled trial testing the efficacy on surrogate markers of HIV progression of the combination didanosine (2',3'-dideoxyinosine or DDI) plus stavudine (2',3'-didehydro-2',3'-dideoxythymidine or D4T) with or without hydroxyurea. The primary end point was a reduction of HIV RNA levels to below 200 copies/ml after 12 weeks of treatment. The results showed that the triple combination was associated with a more profound decrease in HIV RNA with an increased proportion of patients with viraemia < 200 copies/ml. This effect persisted for the majority of the patients after a 48 week follow-up. In contrast, the increase in CD4 cell counts was less in patients treated with hydroxyurea because of lymphopenia, and adverse events were more frequent in hydroxyurea-treated patients. In conclusion, the addition of hydroxyurea consistently improved the antiviral activity of the didanosine/stavudine combination over a 48 week follow-up. Increased toxicity and decreased effect on CD4 cell counts might inspire caution.

Keywords
  • Anti-HIV Agents/adverse effects/therapeutic use
  • CD4 Lymphocyte Count
  • Didanosine/adverse effects/ therapeutic use
  • Drug Synergism
  • Drug Therapy, Combination
  • Follow-Up Studies
  • HIV Infections/ drug therapy
  • Hiv-1
  • Humans
  • Hydroxyurea/adverse effects/ therapeutic use
  • RNA, Viral/blood
  • Reverse Transcriptase Inhibitors/adverse effects/therapeutic use
  • Stavudine/adverse effects/ therapeutic use
Citation (ISO format)
RUTSCHMANN, Olivier Thierry et al. Didanosine plus stavudine with or without hydroxyurea in HIV-1-infected patients: 1 year follow-up. Swiss HIV Cohort Study. In: Antiviral therapy, 1998, vol. 3, n° Suppl 4, p. 65–67.
Identifiers
ISSN of the journal1359-6535
421views
0downloads

Technical informations

Creation07/12/2010 2:37:16 PM
First validation07/12/2010 2:37:16 PM
Update time03/14/2023 3:54:43 PM
Status update03/14/2023 3:54:43 PM
Last indexation01/15/2024 8:52:58 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack