Scientific article

Comparative secretome of ovarian serous carcinoma: Gelsolin in the spotlight

Published inOncology Letters, vol. 13, no. 6, p. 4965-4973
Publication date2017

Ovarian cancer is one of the most common types of reproductive cancer, and has the highest mortality rate amongst gynecological cancer subtypes. The majority of ovarian cancers are diagnosed at an advanced stage, resulting in a five‑year survival rate of ~30%. Early diagnosis of ovarian cancer has improved the five‑year survival rate to ≥90%, thus the current imperative requirement is to identify biomarkers that would allow the early detection, diagnosis and monitoring of the progression of the disease, or of novel targets for therapy. In the present study, secreted proteins from purified ovarian control, benign and cancer cells were investigated by mass spectrometry, in order to identify novel specific markers that are easy to quantify in patients sera. A total of nine proteins revealed significant differential secretion from control and benign cells, in comparison with ovarian cancer cells. The mRNA expression levels of three of these proteins (Dickkopf protein 3, heat shock protein 10 kDa and gelsolin) were subsequently evaluated by reverse transcription‑quantitative polymerase chain reaction. Combined with the protein level in serum, the present study identified that gelsolin may be a useful marker of ovarian cancer.

  • Ovarian cancer
  • Gelsolin
  • Secretome
  • Marker
  • Target
  • Swiss National Science Foundation - 31003A‑127392
Citation (ISO format)
PIERREDON, Sandra et al. Comparative secretome of ovarian serous carcinoma: Gelsolin in the spotlight. In: Oncology Letters, 2017, vol. 13, n° 6, p. 4965–4973. doi: 10.3892/ol.2017.6096
Main files (1)
Article (Published version)
ISSN of the journal1792-1074

Technical informations

Creation04/27/2017 10:30:00 AM
First validation04/27/2017 10:30:00 AM
Update time03/15/2023 1:41:37 AM
Status update03/15/2023 1:41:37 AM
Last indexation08/30/2023 2:46:09 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack