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Scientific article
English

Cefepime plasma concentrations and clinical toxicity: a retrospective cohort study

Published inClinical microbiology and infection, vol. 23, no. 7, p. 454-459
Publication date2017
Abstract

Cefepime remains an important antibiotic for severe bacterial infections, yet some meta-analyses have shown elevated mortality among patients randomized to it. Therapeutic drug monitoring (TDM) of β-lactam antibiotics is increasing, but optimal plasma concentrations remain unknown. We examined clinical outcomes of patients undergoing cefepime TDM in an initial effort to define the drug's toxicity threshold.

Keywords
  • Cefepime
  • Plasma concentration
  • Toxicity
  • Toxicity threshold
  • β-Lactam therapeutic drug monitoring
Citation (ISO format)
HUWYLER, Tibor et al. Cefepime plasma concentrations and clinical toxicity: a retrospective cohort study. In: Clinical microbiology and infection, 2017, vol. 23, n° 7, p. 454–459. doi: 10.1016/j.cmi.2017.01.005
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Article (Published version)
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Identifiers
ISSN of the journal1198-743X
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