Scientific article

English

Cefepime plasma concentrations and clinical toxicity: a retrospective cohort study

ContributorsHuwyler, Tibor; Lenggenhager, Lauriane; Abbas, Mohamed; Ing Lorenzini, Kuntheavy

; Hughes, Sarah; Huttner, Benedikt

; Karmime, Abderrahim; Uckay, Ilker; Von Dach, Elodie; Lescuyer, Pierre

; Harbarth, Stéphan Juergen

; Huttner, Ann-Kristin

Published inClinical microbiology and infection, vol. 23, no. 7, p. 454-459

Publication date2017

Abstract

Cefepime remains an important antibiotic for severe bacterial infections, yet some meta-analyses have shown elevated mortality among patients randomized to it. Therapeutic drug monitoring (TDM) of β-lactam antibiotics is increasing, but optimal plasma concentrations remain unknown. We examined clinical outcomes of patients undergoing cefepime TDM in an initial effort to define the drug's toxicity threshold.

Keywords

Cefepime
Plasma concentration
Toxicity
Toxicity threshold
β-Lactam therapeutic drug monitoring

Affiliation entities

Research groups

Citation (ISO format)

HUWYLER, Tibor et al. Cefepime plasma concentrations and clinical toxicity: a retrospective cohort study. In: Clinical microbiology and infection, 2017, vol. 23, n° 7, p. 454–459. doi: 10.1016/j.cmi.2017.01.005

Article (Published version)

Identifiers

PID : unige:93761
DOI : 10.1016/j.cmi.2017.01.005
PMID : 28111294

Journal ISSN1198-743X

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Creation08/03/2017 14:27:00

First validation08/03/2017 14:27:00

Update time15/03/2023 01:37:19

Status update15/03/2023 01:37:19

Last indexation31/10/2024 06:48:38