Cefepime plasma concentrations and clinical toxicity: a retrospective cohort study

Article Article scientifique Article Cefepime plasma concentrations and clinical toxicity: a retrospective cohort study eng 2017 author Huwyler Tibor 715821 author Lenggenhager Lauriane 700310 author Abbas Mohamed 528404 author Ing Lorenzini Kuntheavy 0000-0001-8472-7714 510277 author Hughes Sarah 708455 author Huttner Benedikt 0000-0002-1749-9464 666500 author Karmime Abderrahim 29133 author Uckay Ilker 134868 author Von Dach Elodie 591850 Elodie Von Dach-Saouter author Lescuyer Pierre 0000-0001-6986-8738 562350 author Harbarth Stéphan Juergen 0000-0002-3551-1025 93885 author Huttner Ann-Kristin 721742 454-459 10.1016/j.cmi.2017.01.005 28111294 1198-743X Cefepime remains an important antibiotic for severe bacterial infections, yet some meta-analyses have shown elevated mortality among patients randomized to it. Therapeutic drug monitoring (TDM) of β-lactam antibiotics is increasing, but optimal plasma concentrations remain unknown. We examined clinical outcomes of patients undergoing cefepime TDM in an initial effort to define the drug's toxicity threshold. Cefepime Plasma concentration Toxicity Toxicity threshold β-Lactam therapeutic drug monitoring Dewey 616 Dewey 617 56 Département de médecine 221 57 Département de chirurgie 222 false 211 Auto-immunité, inflammation et athérosclérose 270 302 Groupe Desmeules Jules (pharmacologie/toxicologie) 567 955 Mécanismes physiopathologiques de l'arthrose 960 Clinical microbiology and infection 23 7 65c241c0-189c-492a-92e3-d54b2c0c0e70 Article (Published version) Restricted 1-s2.0-S1198743X17300149-main.pdf 320302 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de chirurgie

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Cefepime plasma concentrations and clinical toxicity: a retrospective cohort study	Clinical microbiology and infection			2017	653	4

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Hughes, Sarah