Scientific article

The calcium signal and neutrophil activation

Published inClinical biochemistry, vol. 23, no. 2, p. 159-166
Publication date1990

The cytosolic free calcium concentration, [Ca2+]i in phagocytic cells (e.g. neutrophils, human leukemic cell line HL-60) is an important determinant of cellular activity. In resting phagocytes [Ca2+]i is low (approximately 100 nM), but in response to occupation of cell surface receptors, it rises to micromolar levels, thereby activating a variety of cellular functions. The increases in [Ca2+]i consist of two components: an immediate that is independent of extracellular Ca2+, and a more delayed that is abolished by the removal of extracellular Ca2+. These two components reflect the involvement of two subcellular structures in intracellular Ca2+ homeostasis: an intracellular Ca2+ store, referred to as the calciosome; and the plasma membrane. The function of the intracellular Ca2(+)-store depends on a Ca2(+)-pump, functionally and immunologically related to the cardiac sarcoplasmic reticulum Ca2(+)-ATPase, a Ca2(+)-storage protein, similar to muscle calsequestrin, and a Ca2(+)-release channel, which is sensitive to inositol 1,4,5-trisphosphate. The Ca2(+)-regulatory function of the plasma membrane depends on a Ca2+ pump, similar to the erythrocyte-type Ca2(+)-ATPase, and a Ca2+ channel; the activity of the Ca2+ channel is closely coupled to phosphatidylinositol turnover.

  • Calcium/ metabolism
  • Cell Communication/ physiology
  • Humans
  • Neutrophils/ metabolism
Citation (ISO format)
KRAUSE, Karl-Heinz et al. The calcium signal and neutrophil activation. In: Clinical biochemistry, 1990, vol. 23, n° 2, p. 159–166.
ISSN of the journal0009-9120

Technical informations

Creation07/12/2010 2:37:00 PM
First validation07/12/2010 2:37:00 PM
Update time03/14/2023 3:54:30 PM
Status update03/14/2023 3:54:30 PM
Last indexation01/15/2024 8:51:35 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack