UNIGE document Scientific Article
previous document  unige:9354  next document
add to browser collection
Title

Primary prevention of Pneumocystis carinii pneumonia by inhalation of pentamidine. Preliminary results from a placebo-controlled randomized trial. Swiss Group for Clinical Studies on AIDS

Authors
Chopard, P.
Chave, J. P.
Furrer, H. J.
Opravil, M.
Hilti, P.
Vernazza, P.
Lazzarin, A.
Published in Medizinische Klinik. 1990, vol. 85, no. Suppl 2, p. 268-270
Abstract Patients with AIDS but without pneumocystis carinii pneumonia, patients with advanced AIDS-related complex (ARC), and asymptomatic patients with less than 200 CD4-positive lymphocytes/mm3 were randomized to one of two groups: group I: Inhalation of 300 mg of pentamidine every 28 days; group II: Inhalation of placebo (300 mg of Na isethionate) every 28 days. From May to November 28, 1989, 160 patients have entered the trial. Inhalations were well tolerated, with only a 6% use of bronchodilators and a 15% incidence of cough. Until now five patients died, none of them drug related. So far, six patients have developed pneumocystis carinii pneumonia; four of these were on pentamidine, and two on placebo. Five of the six cases occurred before the second inhalation. Recruitment will continue until 250 patients are enrolled.
Keywords Administration, InhalationHIV Infections/ complicationsHumansOpportunistic Infections/ prevention & controlPentamidine/ administration & dosagePneumonia, Pneumocystis/ prevention & controlRandomized Controlled Trials as Topic
Identifiers
PMID: 2197536
Full text
This document has no fulltext available yet, but you can contact its author by using the form below.
Structures
Citation
(ISO format)
HIRSCHEL, Bernard et al. Primary prevention of Pneumocystis carinii pneumonia by inhalation of pentamidine. Preliminary results from a placebo-controlled randomized trial. Swiss Group for Clinical Studies on AIDS. In: Medizinische Klinik, 1990, vol. 85, n° Suppl 2, p. 268-270. https://archive-ouverte.unige.ch/unige:9354

126 hits

0 download

Update

Deposited on : 2010-07-12

Export document
Format :
Citation style :