UNIGE document Scientific Article
previous document  unige:93269  next document
add to browser collection

Insulin and Glucagon: Partners for Life

Holst, Jens Juul
Holland, William
Gromada, Jesper
Lee, Young
Unger, Roger H
Yan, Hai
Sloop, Kyle W
Kieffer, Timothy J
show hidden authors show all authors [1 - 10]
Published in Endocrinology. 2017, vol. 158, no. 4, p. 696-701
Abstract In August 2016, several leaders in glucagon biology gathered for the European Association for the Study of Diabetes Hagedorn Workshop in Oxford, England. A key point of discussion focused around the need for basal insulin to allow for the therapeutic benefit of glucagon blockade in the treatment of diabetes. Among the most enlightening experimental results presented were findings from studies where glucagon receptor-deficient mice were administered streptozotocin to destroy pancreatic beta cells or had undergone diphtheria toxin-induced beta cell ablation. Here, key features of the discussion are summarized as we reached a consensus. Agents that antagonize glucagon may be of great benefit for the treatment of diabetes; however, sufficient levels of basal insulin are required for their therapeutic efficacy.
PMID: 28323959
Full text
Article (Published version) (2.2 MB) - public document Free access
Research group Types cellulaires pancréatiques pendant l'ontogénèse (522)
(ISO format)
HOLST, Jens Juul et al. Insulin and Glucagon: Partners for Life. In: Endocrinology, 2017, vol. 158, n° 4, p. 696-701. https://archive-ouverte.unige.ch/unige:93269

97 hits



Deposited on : 2017-04-06

Export document
Format :
Citation style :