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In Ovo Progression of Borderline Ovarian Tumors

Contributors

Meynier, Sonia; Undurraga Malinverno, Manuela Stefania; Tille, Jean-Christophe; Petignat, Patrick; Cohen, Marie-Benoîte

Published in

Journal of oncology translational research, vol. 2

Publication date

2016

Abstract

Objective: Borderline ovarian tumors (BOTs) are generally considered to be non-invasive tumors with low malignancy potential. However, studies show that BOTs have the ability to progress to low-grade carcinomas and gain the potential to invade surrounding tissue and to metastasize. Here, we investigate whether a patient derived serous BOT (SBOT) could progress in low-grade serous carcinoma (LGSC) through in vitro and in ovo characterization. Methods: Ovarian cancer cell line from a SBOT, named OCAM, were isolated and characterized by PCR, migration assay and chick chorioallantoic membrane (CAM) assay. Results: OCAM cells express carcinoma characteristics and form a tumor in CAM. Moreover, OCAM cells get into membrane of chicken suggesting invasive properties. Conclusion: SBOTs could a precursor of LGSC involving consequences in adaptation of treatment provided by clinician.

Keywords

  • Borderline tumor
  • Ovarian
  • Low grade
  • Progression

UNIGE affiliation entities

UNIGE research groups

Citation (ISO format)

MEYNIER, Sonia et al. In Ovo Progression of Borderline Ovarian Tumors. In: Journal of oncology translational research, 2016, vol. 2.

Main files (1)

Article (Published version)

Identifiers

  • PID : unige:93082

Journal ISSN

2476-2261
540views
336downloads

Technical informations

Creation

27/03/2017 14:33:00

First validation

27/03/2017 14:33:00

Update

15/03/2023 01:31:29

Status update

15/03/2023 01:31:29

Last indexation

31/10/2024 06:36:14
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