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In Ovo Progression of Borderline Ovarian Tumors

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Published in Journal of Oncology Translational Research. 2016, vol. 2
Abstract Objective: Borderline ovarian tumors (BOTs) are generally considered to be non-invasive tumors with low malignancy potential. However, studies show that BOTs have the ability to progress to low-grade carcinomas and gain the potential to invade surrounding tissue and to metastasize. Here, we investigate whether a patient derived serous BOT (SBOT) could progress in low-grade serous carcinoma (LGSC) through in vitro and in ovo characterization. Methods: Ovarian cancer cell line from a SBOT, named OCAM, were isolated and characterized by PCR, migration assay and chick chorioallantoic membrane (CAM) assay. Results: OCAM cells express carcinoma characteristics and form a tumor in CAM. Moreover, OCAM cells get into membrane of chicken suggesting invasive properties. Conclusion: SBOTs could a precursor of LGSC involving consequences in adaptation of treatment provided by clinician.
Keywords Borderline tumorOvarianLow gradeProgression
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Research group Laboratoire de biologie des tumeurs gynécologiques et du développement (927)
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MEYNIER, Sonia et al. In Ovo Progression of Borderline Ovarian Tumors. In: Journal of Oncology Translational Research, 2016, vol. 2. https://archive-ouverte.unige.ch/unige:93082

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Deposited on : 2017-04-04

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