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Alternative Strategies to Reversed-Phase Liquid Chromatography for the Analysis of Pharmaceutical Compounds

Contributeurs/tricesGuillarme, Davy; Veuthey, Jean-Luc
Publié dansAmerican pharmaceutical review, vol. 20, p. 46-51
Date de publication2017
Résumé

Reversed phase liquid chromatography (RPLC) is the gold standard analytical strategy in the pharmaceutical industry. In this contribution, we will describe two alternative chromatographic approaches, namely hydrophilic interaction chromatography (HILIC) and supercritical fluid chromatography (SFC), which are more and more commonly used in pharmaceutical analysis. Among their advantages, these two strategies offer better retention of polar substances, alternative selectivities and enhanced MS sensitivity, in comparison with RPLC.

Mots-clés
  • Supercritical fluid chromatography
  • hydrophilic interaction chroma-tography
  • SFC
  • HILIC
Groupe de recherche
Citation (format ISO)
GUILLARME, Davy, VEUTHEY, Jean-Luc. Alternative Strategies to Reversed-Phase Liquid Chromatography for the Analysis of Pharmaceutical Compounds. In: American pharmaceutical review, 2017, vol. 20, p. 46–51.
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Article (Published version)
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Identifiants
  • PID : unige:92895
ISSN du journal1099-8012
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Informations techniques

Création27/03/2017 10:15:00
Première validation27/03/2017 10:15:00
Heure de mise à jour15/03/2023 01:30:15
Changement de statut15/03/2023 01:30:15
Dernière indexation16/01/2024 23:34:57
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