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Interrupting highly active antiretroviral therapy in patients with HIV

Ananworanich, Jintanat
Published in Expert Review of Anti-infective Therapy. 2005, vol. 3, no. 1, p. 51-60
Abstract Scheduled treatment interruptions are preplanned interruptions of antiretroviral treatment, which may be directed by time (e.g., cycles of 8 weeks on treatment and 8 weeks off treatment); the concentration of CD4+ lymphocytes (the CD4 count); HIV-1 RNA concentration (viral load); or other factors. This review covers the rationale of scheduled treatment interruptions and the different strategies that have been explored. It examines the issue of autovaccination, resistance and other risks and benefits. Scheduled-treatment-interruption studies in three populations are discussed: patients who initiated highly active antiretroviral therapy during acute HIV infection; patients with successfully treated chronic HIV infection; and patients with highly active antiretroviral therapy failure.
Keywords Antiretroviral Therapy, Highly Active/ methodsDrug Administration ScheduleHIV Infections/ drug therapy/virologyHumans
PMID: 15757457
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ANANWORANICH, Jintanat, HIRSCHEL, Bernard. Interrupting highly active antiretroviral therapy in patients with HIV. In: Expert Review of Anti-infective Therapy, 2005, vol. 3, n° 1, p. 51-60. https://archive-ouverte.unige.ch/unige:9285

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Deposited on : 2010-07-12

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