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Title

The Gli code: an information nexus regulating cell fate, stemness and cancer

Authors
Stecca, Barbara
Published in Trends in Cell Biology. 2007, vol. 17, no. 9, p. 438-447
Abstract The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape. Hh and other inputs are then just ways to modify the Gli code. Recent data confirm this idea and suggest that the Gli code regulates stemness and also tumor progression and metastatic growth, opening exciting possibilities for both regenerative medicine and novel anticancer therapies.
Keywords AnimalsBody PatterningCell AgingCell Differentiation/physiologyDisease ProgressionGene Expression Regulation, DevelopmentalHedgehog Proteins/ metabolismHumansNeoplasm MetastasisNeoplasms/metabolism/pathology/physiopathology/therapyOncogene Proteins/genetics/ metabolismOncogenesSignal Transduction/ physiologyStem Cells/cytology/ physiologyTrans-Activators/genetics/ metabolism
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PMID: 17845852
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RUIZ ALTABA, Ariel, MAS, Christophe, STECCA, Barbara. The Gli code: an information nexus regulating cell fate, stemness and cancer. In: Trends in Cell Biology, 2007, vol. 17, n° 9, p. 438-447. https://archive-ouverte.unige.ch/unige:9254

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Deposited on : 2010-07-12

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