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Scientific article
Open access
English

The Gli code: an information nexus regulating cell fate, stemness and cancer

Published inTrends in cell biology, vol. 17, no. 9, p. 438-447
Publication date2007
Abstract

The Gli code hypothesis postulates that the three vertebrate Gli transcription factors act together in responding cells to integrate intercellular Hedgehog (Hh) and other signaling inputs, resulting in the regulation of tissue pattern, size and shape. Hh and other inputs are then just ways to modify the Gli code. Recent data confirm this idea and suggest that the Gli code regulates stemness and also tumor progression and metastatic growth, opening exciting possibilities for both regenerative medicine and novel anticancer therapies.

Keywords
  • Animals
  • Body Patterning
  • Cell Aging
  • Cell Differentiation/physiology
  • Disease Progression
  • Gene Expression Regulation, Developmental
  • Hedgehog Proteins/ metabolism
  • Humans
  • Neoplasm Metastasis
  • Neoplasms/metabolism/pathology/physiopathology/therapy
  • Oncogene Proteins/genetics/ metabolism
  • Oncogenes
  • Signal Transduction/ physiology
  • Stem Cells/cytology/ physiology
  • Trans-Activators/genetics/ metabolism
Citation (ISO format)
RUIZ ALTABA, Ariel, MAS, Christophe, STECCA, Barbara. The Gli code: an information nexus regulating cell fate, stemness and cancer. In: Trends in cell biology, 2007, vol. 17, n° 9, p. 438–447. doi: 10.1016/j.tcb.2007.06.007
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ISSN of the journal0962-8924
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