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Title

5-HT2A receptor SPECT imaging with [¹²³I]R91150 under P-gp inhibition with tariquidar: More is better?
Authors
Tsartsalis, Stergios
Tournier, Benjamin
Huynh-Gatz, Trinh
Dumas, Noe
Ginovart, Nathalie
Moulin-Sallanon, Marcelle
Millet, Philippe
Published in Nuclear Medicine and Biology. 2016, vol. 43, no. 1, p. 81-88
Abstract Pharmacological P-glycoprotein (P-gp) inhibition with tariquidar (TQD) is considered a promising strategy for the augmentation of radiotracer brain uptake. However, a region-dependent effect may compromise the robustness of quantitative studies. For this reason, we studied the effect of a TQD pretreatment on 5-HT2A imaging with [(123)I]R91150 and compared results with those obtained in Mdr1a knock-out (KO) rats.
Keywords Animals — Gene Knockout Techniques — Iodine Radioisotopes — Male — P-Glycoprotein/antagonists & inhibitors/deficiency/genetics — Piperidines — Quinolines/pharmacology — Rats — Rats, Sprague-Dawley — Receptor, Serotonin, 5-HT2A/metabolism — Tomography, Emission-Computed, Single-Photon/methods
Identifiers
PMID: 26454782
Full text
Article (Published version) (642 Kb) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de psychiatrie
Research groups Neuroimagerie moléculaire en psychiatrie (983)
Imagerie de la transmission dopaminergique dans les troubles addictifs (989)
Citation
(ISO format) 		TSARTSALIS, Stergios et al. 5-HT2A receptor SPECT imaging with [¹²³I]R91150 under P-gp inhibition with tariquidar: More is better?. In: Nuclear Medicine and Biology, 2016, vol. 43, n° 1, p. 81-88. https://archive-ouverte.unige.ch/unige:92493

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Deposited on : 2017-03-10

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