Scientific article
English

5-HT2A receptor SPECT imaging with [¹²³I]R91150 under P-gp inhibition with tariquidar: More is better?

Published inNuclear medicine and biology, vol. 43, no. 1, p. 81-88
Publication date2016
Abstract

Pharmacological P-glycoprotein (P-gp) inhibition with tariquidar (TQD) is considered a promising strategy for the augmentation of radiotracer brain uptake. However, a region-dependent effect may compromise the robustness of quantitative studies. For this reason, we studied the effect of a TQD pretreatment on 5-HT2A imaging with [(123)I]R91150 and compared results with those obtained in Mdr1a knock-out (KO) rats.

Keywords
  • Animals
  • Gene Knockout Techniques
  • Iodine Radioisotopes
  • Male
  • P-Glycoprotein/antagonists & inhibitors/deficiency/genetics
  • Piperidines
  • Quinolines/pharmacology
  • Rats
  • Rats, Sprague-Dawley
  • Receptor, Serotonin, 5-HT2A/metabolism
  • Tomography, Emission-Computed, Single-Photon/methods
Citation (ISO format)
TSARTSALIS, Stergios et al. 5-HT2A receptor SPECT imaging with [¹²³I]R91150 under P-gp inhibition with tariquidar: More is better? In: Nuclear medicine and biology, 2016, vol. 43, n° 1, p. 81–88. doi: 10.1016/j.nucmedbio.2015.09.003
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Article (Published version)
accessLevelRestricted
Identifiers
Journal ISSN0969-8051
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