5-HT2A receptor SPECT imaging with [¹²³I]R91150 under P-gp inhibition with tariquidar: More is better?

Tsartsalis, Stergios; Tournier, Benjamin; Huynh-Gatz, Trinh; Dumas, Noe; Ginovart, Nathalie; Moulin-Sallanon, Marcelle; Millet, Philippe

doi:10.1016/j.nucmedbio.2015.09.003

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Title		5-HT2A receptor SPECT imaging with [¹²³I]R91150 under P-gp inhibition with tariquidar: More is better?
Authors		Tsartsalis, Stergios Tournier, Benjamin Huynh-Gatz, Trinh Dumas, Noe Ginovart, Nathalie Moulin-Sallanon, Marcelle Millet, Philippe
Published in		Nuclear Medicine and Biology. 2016, vol. 43, no. 1, p. 81-88
Abstract		Pharmacological P-glycoprotein (P-gp) inhibition with tariquidar (TQD) is considered a promising strategy for the augmentation of radiotracer brain uptake. However, a region-dependent effect may compromise the robustness of quantitative studies. For this reason, we studied the effect of a TQD pretreatment on 5-HT2A imaging with [(123)I]R91150 and compared results with those obtained in Mdr1a knock-out (KO) rats.
Keywords		Animals — Gene Knockout Techniques — Iodine Radioisotopes — Male — P-Glycoprotein/antagonists & inhibitors/deficiency/genetics — Piperidines — Quinolines/pharmacology — Rats — Rats, Sprague-Dawley — Receptor, Serotonin, 5-HT2A/metabolism — Tomography, Emission-Computed, Single-Photon/methods
Identifiers		DOI: 10.1016/j.nucmedbio.2015.09.003 PMID: 26454782
Full text		Article (Published version) (642 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie
Research groups		Neuroimagerie moléculaire en psychiatrie (983) Imagerie de la transmission dopaminergique dans les troubles addictifs (989)
Citation (ISO format)		TSARTSALIS, Stergios et al. 5-HT2A receptor SPECT imaging with [¹²³I]R91150 under P-gp inhibition with tariquidar: More is better?. In: Nuclear Medicine and Biology, 2016, vol. 43, n° 1, p. 81-88. doi: 10.1016/j.nucmedbio.2015.09.003 https://archive-ouverte.unige.ch/unige:92493