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Titles list5-HT2A receptor SPECT imaging with [¹²³I]R91150 under P-gp inhibition with tariquidar: More is better?
Titles list5-HT2A receptor SPECT imaging with [¹²³I]R91150 under P-gp inhibition with tariquidar: More is better?
Scientific Article
unige:92493 
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5-HT2A receptor SPECT imaging with [¹²³I]R91150 under P-gp inhibition with tariquidar: More is better? |
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| Authors | ||
| Published in | Nuclear Medicine and Biology. 2016, vol. 43, no. 1, p. 81-88 | |
| Abstract | Pharmacological P-glycoprotein (P-gp) inhibition with tariquidar (TQD) is considered a promising strategy for the augmentation of radiotracer brain uptake. However, a region-dependent effect may compromise the robustness of quantitative studies. For this reason, we studied the effect of a TQD pretreatment on 5-HT2A imaging with [(123)I]R91150 and compared results with those obtained in Mdr1a knock-out (KO) rats. | |
| Keywords | Animals — Gene Knockout Techniques — Iodine Radioisotopes — Male — P-Glycoprotein/antagonists & inhibitors/deficiency/genetics — Piperidines — Quinolines/pharmacology — Rats — Rats, Sprague-Dawley — Receptor, Serotonin, 5-HT2A/metabolism — Tomography, Emission-Computed, Single-Photon/methods | |
| Identifiers | PMID: 26454782 | |
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| Structures | ||
| Research groups | Neuroimagerie moléculaire en psychiatrie (983) Imagerie de la transmission dopaminergique dans les troubles addictifs (989) | |
| Citation (ISO format) | TSARTSALIS, Stergios et al. 5-HT2A receptor SPECT imaging with [¹²³I]R91150 under P-gp inhibition with tariquidar: More is better?. In: Nuclear Medicine and Biology, 2016, vol. 43, n° 1, p. 81-88. https://archive-ouverte.unige.ch/unige:92493 |
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