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5-HT2A receptor SPECT imaging with [¹²³I]R91150 under P-gp inhibition with tariquidar: More is better?

Huynh-Gatz, Trinh
Moulin-Sallanon, Marcelle
Published in Nuclear medicine and biology. 2016, vol. 43, no. 1, p. 81-88
Abstract Pharmacological P-glycoprotein (P-gp) inhibition with tariquidar (TQD) is considered a promising strategy for the augmentation of radiotracer brain uptake. However, a region-dependent effect may compromise the robustness of quantitative studies. For this reason, we studied the effect of a TQD pretreatment on 5-HT2A imaging with [(123)I]R91150 and compared results with those obtained in Mdr1a knock-out (KO) rats.
Keywords AnimalsGene Knockout TechniquesIodine RadioisotopesMaleP-Glycoprotein/antagonists & inhibitors/deficiency/geneticsPiperidinesQuinolines/pharmacologyRatsRats, Sprague-DawleyReceptor, Serotonin, 5-HT2A/metabolismTomography, Emission-Computed, Single-Photon/methods
PMID: 26454782
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Research groups Imagerie de la transmission dopaminergique dans les troubles addictifs (989)
Neuroimagerie moléculaire en psychiatrie (983)
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TSARTSALIS, Stergios et al. 5-HT2A receptor SPECT imaging with [¹²³I]R91150 under P-gp inhibition with tariquidar: More is better?. In: Nuclear medicine and biology, 2016, vol. 43, n° 1, p. 81-88. doi: 10.1016/j.nucmedbio.2015.09.003 https://archive-ouverte.unige.ch/unige:92493

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Deposited on : 2017-03-10

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