en
Scientific article
English

A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic mice

Published inDiabetologia, vol. 37, no. 12, p. 1277-1279
Publication date1994
Abstract

While transgenic mice expressing tumour necrosis factor-alpha under the control of the beta-cell-specific insulin promoter display a marked lymphocytic infiltration of the islets, they never develop insulin-dependent diabetes mellitus (IDDM). In striking contrast, "double" transgenic mice whose beta cells express both tumour necrosis factor-alpha as well as the co-stimulatory B7-1 molecule all develop IDDM at an early age. Furthermore, administration of anti-CD8 but not anti-CD4 immunoglobulins prevents diabetes onset. These results indicate that while tumour necrosis factor-alpha induced lymphocytic infiltration is not sufficient to effect beta-cell destruction, locally co-stimulated islet-infiltrating CD8+ T lymphocytes could play a critical role in the development of IDDM.

Keywords
  • Animals
  • Antigens, CD4/ immunology
  • Antigens, CD8/ immunology
  • Antigens, CD80/ biosynthesis/immunology
  • Autoimmune Diseases/ immunology/prevention & control
  • Blood Glucose/metabolism
  • CD4-Positive T-Lymphocytes/ immunology
  • CD8-Positive T-Lymphocytes/ immunology
  • Diabetes Mellitus, Type 1/ immunology/prevention & control
  • Female
  • Immunoglobulins, Intravenous/pharmacology
  • Islets of Langerhans/immunology
  • Male
  • Mice
  • Mice, Transgenic
  • Tumor Necrosis Factor-alpha/ biosynthesis/immunology
Citation (ISO format)
HERRERA, Pedro Luis et al. A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic mice. In: Diabetologia, 1994, vol. 37, n° 12, p. 1277–1279.
Identifiers
ISSN of the journal0012-186X
609views
0downloads

Technical informations

Creation07/12/2010 2:36:18 PM
First validation07/12/2010 2:36:18 PM
Update time03/14/2023 3:53:48 PM
Status update03/14/2023 3:53:48 PM
Last indexation01/15/2024 8:48:09 PM
All rights reserved by Archive ouverte UNIGE and the University of GenevaunigeBlack