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Title

A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic mice

Authors
Harlan, D. M.
Fossati-Jimack, Liliane
Published in Diabetologia. 1994, vol. 37, no. 12, p. 1277-1279
Abstract While transgenic mice expressing tumour necrosis factor-alpha under the control of the beta-cell-specific insulin promoter display a marked lymphocytic infiltration of the islets, they never develop insulin-dependent diabetes mellitus (IDDM). In striking contrast, "double" transgenic mice whose beta cells express both tumour necrosis factor-alpha as well as the co-stimulatory B7-1 molecule all develop IDDM at an early age. Furthermore, administration of anti-CD8 but not anti-CD4 immunoglobulins prevents diabetes onset. These results indicate that while tumour necrosis factor-alpha induced lymphocytic infiltration is not sufficient to effect beta-cell destruction, locally co-stimulated islet-infiltrating CD8+ T lymphocytes could play a critical role in the development of IDDM.
Keywords AnimalsAntigens, CD4/ immunologyAntigens, CD8/ immunologyAntigens, CD80/ biosynthesis/immunologyAutoimmune Diseases/ immunology/prevention & controlBlood Glucose/metabolismCD4-Positive T-Lymphocytes/ immunologyCD8-Positive T-Lymphocytes/ immunologyDiabetes Mellitus, Type 1/ immunology/prevention & controlFemaleImmunoglobulins, Intravenous/pharmacologyIslets of Langerhans/immunologyMaleMiceMice, TransgenicTumor Necrosis Factor-alpha/ biosynthesis/immunology
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PMID: 7534735
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HERRERA, Pedro Luis et al. A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic mice. In: Diabetologia, 1994, vol. 37, n° 12, p. 1277-1279. https://archive-ouverte.unige.ch/unige:9199

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Deposited on : 2010-07-12

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