en
Scientific article
English

Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site

Published inDiabetologia, vol. 17, no. 2, p. 97-99
Publication date1979
Abstract

The absorption of subcutaneously injected insulin was examined by injecting semisynthetic [3H] insulin in anaesthetized pigs and subsequently analysing the tissue excised from the injection site. Contrary to previously accepted views, a significant proportion of insulin was degraded at the injection site. The disappearance of intact [3H] insulin from the injection site followed a monoexponential function with a half-time of 59 min.

Keywords
  • Absorption
  • Animals
  • Injections, Subcutaneous
  • Insulin/administration & dosage/ metabolism
  • Kinetics
  • Swine
  • Tritium
Citation (ISO format)
BERGER, M. et al. Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site. In: Diabetologia, 1979, vol. 17, n° 2, p. 97–99. doi: 10.1007/bf01222209
Identifiers
ISSN of the journal0012-186X
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