Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site

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Title		Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site
Authors		Berger, M. Halban, Philippe A. Girardier, L. Seydoux, J. Offord, R. E. Renold, A. E.
Published in		Diabetologia. 1979, vol. 17, no. 2, p. 97-99
Abstract		The absorption of subcutaneously injected insulin was examined by injecting semisynthetic [3H] insulin in anaesthetized pigs and subsequently analysing the tissue excised from the injection site. Contrary to previously accepted views, a significant proportion of insulin was degraded at the injection site. The disappearance of intact [3H] insulin from the injection site followed a monoexponential function with a half-time of 59 min.
Keywords		Absorption — Animals — Injections, Subcutaneous — Insulin/administration & dosage/ metabolism — Kinetics — Swine — Tritium
Identifiers		DOI: 10.1007/bf01222209 PMID: 488572
Full text		Other version: http://www.springerlink.com/content/q3503w2624510540/
Structures		Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement
Citation (ISO format)		BERGER, M. et al. Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site. In: Diabetologia, 1979, vol. 17, n° 2, p. 97-99. https://archive-ouverte.unige.ch/unige:9139

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