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Title

Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site

Authors
Berger, M.
Girardier, L.
Seydoux, J.
Offord, R. E.
Renold, A. E.
Published in Diabetologia. 1979, vol. 17, no. 2, p. 97-99
Abstract The absorption of subcutaneously injected insulin was examined by injecting semisynthetic [3H] insulin in anaesthetized pigs and subsequently analysing the tissue excised from the injection site. Contrary to previously accepted views, a significant proportion of insulin was degraded at the injection site. The disappearance of intact [3H] insulin from the injection site followed a monoexponential function with a half-time of 59 min.
Keywords AbsorptionAnimalsInjections, SubcutaneousInsulin/administration & dosage/ metabolismKineticsSwineTritium
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PMID: 488572
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BERGER, M. et al. Absorption kinetics of subcutaneously injected insulin. Evidence for degradation at the injection site. In: Diabetologia, 1979, vol. 17, n° 2, p. 97-99. https://archive-ouverte.unige.ch/unige:9139

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Deposited on : 2010-07-12

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