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Title

Age dependence of human gastrocnemius Mg2+: fitting 31P-NMR spectra using quantum mechanics-based prior knowledge

Authors
Graveron-Demilly, D
Published in Journal of Physiological Anthropology and Applied Human Science. 2001, vol. 20, no. 5, p. 275-283
Abstract The age dependence of human gastrocnemius Mg2+ concentration is demonstrated. To quantitate Mg2+ concentration, an original and accurate fitting algorithm using quantum mechanics-based prior knowledge is detailed. In a group of 28 volunteers (14 females) in the age range 5-80 years, pH, PCr/ATP and Pi/ATP values in the gastrocnemius were 7.02 +/- 0.02 pH, 4.16 +/- 0.33 and 0.13 +/- 0.02, respectively and independent of age and sex. By contrast, intracellular Mg2+ concentration (mM) decreased linearly (p < 0.05) with age (Mg2+ = 0.7803 +/- 0.0247-0.0027 +/- 0.0005 * age). No difference was found between sexes. From these results, it follows that care must be taken when comparing muscle Mg2+ data from subjects of different age. The hypothesis can be put forward that during aging insufficient intake and/or increased depletion of Mg2+ (e.g., intestinal hypoabsorption or urinary leakage) may affect the musculoskeletal system.
Keywords Adenosine Triphosphate/metabolismAdolescentAdultAge FactorsAgedAged, 80 and overAlgorithmsChildChild, PreschoolComputer SimulationFemaleHumansHydrogen-Ion ConcentrationMagnesium/metabolism/physiologyMaleMiddle AgedMonte Carlo MethodMuscle, Skeletal/metabolismNuclear Magnetic Resonance, Biomolecular/methodsPhosphates/metabolismPhosphocreatine/metabolismPhosphorusQuantum Theory
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PMID: 11759266
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Research group Groupe Binzoni Tiziano (radiologie) (234)
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BINZONI, Tiziano et al. Age dependence of human gastrocnemius Mg2+: fitting 31P-NMR spectra using quantum mechanics-based prior knowledge. In: Journal of Physiological Anthropology and Applied Human Science, 2001, vol. 20, n° 5, p. 275-283. https://archive-ouverte.unige.ch/unige:91079

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Deposited on : 2017-01-13

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