

![]() |
Age dependence of human gastrocnemius Mg2+: fitting 31P-NMR spectra using quantum mechanics-based prior knowledge |
|
Authors | ||
Published in | Journal of physiological anthropology and applied human science. 2001, vol. 20, no. 5, p. 275-283 | |
Abstract | The age dependence of human gastrocnemius Mg2+ concentration is demonstrated. To quantitate Mg2+ concentration, an original and accurate fitting algorithm using quantum mechanics-based prior knowledge is detailed. In a group of 28 volunteers (14 females) in the age range 5-80 years, pH, PCr/ATP and Pi/ATP values in the gastrocnemius were 7.02 +/- 0.02 pH, 4.16 +/- 0.33 and 0.13 +/- 0.02, respectively and independent of age and sex. By contrast, intracellular Mg2+ concentration (mM) decreased linearly (p < 0.05) with age (Mg2+ = 0.7803 +/- 0.0247-0.0027 +/- 0.0005 * age). No difference was found between sexes. From these results, it follows that care must be taken when comparing muscle Mg2+ data from subjects of different age. The hypothesis can be put forward that during aging insufficient intake and/or increased depletion of Mg2+ (e.g., intestinal hypoabsorption or urinary leakage) may affect the musculoskeletal system. | |
Keywords | Adenosine Triphosphate/metabolism — Adolescent — Adult — Age Factors — Aged — Aged, 80 and over — Algorithms — Child — Child, Preschool — Computer Simulation — Female — Humans — Hydrogen-Ion Concentration — Magnesium/metabolism/physiology — Male — Middle Aged — Monte Carlo Method — Muscle, Skeletal/metabolism — Nuclear Magnetic Resonance, Biomolecular/methods — Phosphates/metabolism — Phosphocreatine/metabolism — Phosphorus — Quantum Theory | |
Identifiers | PMID: 11759266 | |
Full text | ||
Structures | ||
Research group | Groupe Binzoni Tiziano (radiologie) (234) | |
Citation (ISO format) | BINZONI, Tiziano et al. Age dependence of human gastrocnemius Mg2+: fitting 31P-NMR spectra using quantum mechanics-based prior knowledge. In: Journal of physiological anthropology and applied human science, 2001, vol. 20, n° 5, p. 275-283. https://archive-ouverte.unige.ch/unige:91079 |