Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor

Xuan, Shouhong; Kitamura, Tadahiro; Nakae, Jun; Politi, Katerina; Kido, Yoshiaki; Fisher, P. E.; Morroni, Manrico; Cinti, Saverio; White, M. F.; Herrera, Pedro Luis; Accili, Domenico; Efstratiadis, Argiris

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Title		Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor
Authors		Xuan, Shouhong Kitamura, Tadahiro Nakae, Jun Politi, Katerina Kido, Yoshiaki Fisher, P. E. Morroni, Manrico Cinti, Saverio White, M. F. Herrera, Pedro Luis Accili, Domenico Efstratiadis, Argiris show all authors [1 - 12]
Published in		Journal of Clinical Investigation. 2002, vol. 110, no. 7, p. 1011-1019
Abstract		Defective insulin secretion is a feature of type 2 diabetes that results from inadequate compensatory increase of beta cell mass and impaired glucose-dependent insulin release. beta cell proliferation and secretion are thought to be regulated by signaling through receptor tyrosine kinases. In this regard, we sought to examine the potential proliferative and/or antiapoptotic role of IGFs in beta cells by tissue-specific conditional mutagenesis ablating type 1 IGF receptor (IGF1R) signaling. Unexpectedly, lack of functional IGF1R did not affect beta cell mass, but resulted in age-dependent impairment of glucose tolerance, associated with a decrease of glucose- and arginine-dependent insulin release. These observations reveal a requirement of IGF1R-mediated signaling for insulin secretion.
Keywords		Animals — Exocytosis — Glucose Transporter Type 2 — Insulin/ secretion — Islets of Langerhans/ secretion — Mice — Monosaccharide Transport Proteins/analysis — Phenotype — RNA, Messenger/analysis — Receptor, IGF Type 1/deficiency/genetics/ physiology
Identifiers		DOI: 10.1172/JCI15276 PMID: 12370279
Full text		Article - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Research group		Types cellulaires pancréatiques pendant l'ontogénèse (522)
Citation (ISO format)		XUAN, Shouhong et al. Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. In: Journal of Clinical Investigation, 2002, vol. 110, n° 7, p. 1011-1019. https://archive-ouverte.unige.ch/unige:9103