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Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor

Xuan, Shouhong
Kitamura, Tadahiro
Nakae, Jun
Politi, Katerina
Kido, Yoshiaki
Fisher, P. E.
Morroni, Manrico
Cinti, Saverio
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Published in Journal of Clinical Investigation. 2002, vol. 110, no. 7, p. 1011-1019
Abstract Defective insulin secretion is a feature of type 2 diabetes that results from inadequate compensatory increase of beta cell mass and impaired glucose-dependent insulin release. beta cell proliferation and secretion are thought to be regulated by signaling through receptor tyrosine kinases. In this regard, we sought to examine the potential proliferative and/or antiapoptotic role of IGFs in beta cells by tissue-specific conditional mutagenesis ablating type 1 IGF receptor (IGF1R) signaling. Unexpectedly, lack of functional IGF1R did not affect beta cell mass, but resulted in age-dependent impairment of glucose tolerance, associated with a decrease of glucose- and arginine-dependent insulin release. These observations reveal a requirement of IGF1R-mediated signaling for insulin secretion.
Keywords AnimalsExocytosisGlucose Transporter Type 2Insulin/ secretionIslets of Langerhans/ secretionMiceMonosaccharide Transport Proteins/analysisPhenotypeRNA, Messenger/analysisReceptor, IGF Type 1/deficiency/genetics/ physiology
PMID: 12370279
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Research group Types cellulaires pancréatiques pendant l'ontogénèse (522)
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XUAN, Shouhong et al. Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. In: Journal of Clinical Investigation, 2002, vol. 110, n° 7, p. 1011-1019. https://archive-ouverte.unige.ch/unige:9103

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Deposited on : 2010-07-12

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