Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production

Semplici, Francesca; Mondragon, Angeles; Macintyre, Benedict; Madeyski-Bengston, Katja; Persson-Kry, Anette; Barr, Sara; Ramne, Anna; Marley, Anna; McGinty, James; French, Paul; Soedling, Helen; Yokosuka, Ryohsuke; Gaitan, Julien; Lang, Jochen; Migrenne-Li, Stephanie; Philippe, Erwann; Herrera, Pedro Luis; Magnan, Christophe; da Silva Xavier, Gabriela; Rutter, Guy A

doi:10.1007/s00125-016-4025-1

Scientific article

English

Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production

Published inDiabetologia, vol. 59, no. 9, p. 1938-1947

Publication date2016

Abstract

Per-Arnt-Sim kinase (PASK) is a nutrient-regulated domain-containing protein kinase previously implicated in the control of insulin gene expression and glucagon secretion. Here, we explore the roles of PASK in the control of islet hormone release, by generating mice with selective deletion of the Pask gene in pancreatic beta or alpha cells.

Affiliation entities

Faculté de médecine / Section de médecine fondamentale / Département de médecine génétique et développement

Research groups

Types cellulaires pancréatiques pendant l'ontogénèse (522)

Citation (ISO format)

SEMPLICI, Francesca et al. Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production. In: Diabetologia, 2016, vol. 59, n° 9, p. 1938–1947. doi: 10.1007/s00125-016-4025-1

Article (Published version)

Identifiers

PID : unige:90722
DOI : 10.1007/s00125-016-4025-1
PMID : 27338626

Journal ISSN0012-186X

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Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production

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