en
Scientific article
Review
English

Ventral tegmental area subcircuits process rewarding and aversive experiences

Published inJournal of neurochemistry, vol. 139, p. 1071-1080
Publication date2016
Abstract

The ventral tegmental area is a heterogeneous brain structure that plays a central role in rewarding and aversive experience processing. Studies suggest that several subpopulations within the ventral tegmental area form subcircuits that are differentially involved in rewarding and aversive experiences and that could be individually affected in several neuropsychiatric disorders. Here, we focus on the recent advances concerning the functional description of the three major neuronal subpopulations, in terms of neurotransmitter release, their input and output structures, and their role in controlling specific behavioral outcomes. Several subpopulations within the Ventral Tegmental Area form subcircuits that are differentially involved in rewarding and aversive experiences and that could be individually affected in several neuropsychiatric disorders. We focus on the recent advances concerning the functional description of the three major neuronal subpopulations, their input and output structures, and their role in controlling specific behavioral outcomes. This article is part of a mini review series: "Synaptic Function and Dysfunction in Brain Diseases".

Citation (ISO format)
BARISELLI, Sebastiano et al. Ventral tegmental area subcircuits process rewarding and aversive experiences. In: Journal of neurochemistry, 2016, vol. 139, p. 1071–1080. doi: 10.1111/jnc.13779
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ISSN of the journal0022-3042
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