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Title

SHANK3 controls maturation of social reward circuits in the VTA.

Authors
Pucci, Luca
Viguié, Joanna
Bezzi, Paola
O'Connor, Eoin C
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Published in Nature neuroscience. 2016, vol. 19, no. 7, p. 926-934
Abstract Haploinsufficiency of SHANK3, encoding the synapse scaffolding protein SHANK3, leads to a highly penetrant form of autism spectrum disorder. How SHANK3 insufficiency affects specific neural circuits and how this is related to specific symptoms remains elusive. Here we used shRNA to model Shank3 insufficiency in the ventral tegmental area of mice. We identified dopamine (DA) and GABA cell-type-specific changes in excitatory synapse transmission that converge to reduce DA neuron activity and generate behavioral deficits, including impaired social preference. Administration of a positive allosteric modulator of the type 1 metabotropic glutamate receptors mGluR1 during the first postnatal week restored DA neuron excitatory synapse transmission and partially rescued the social preference defects, while optogenetic DA neuron stimulation was sufficient to enhance social preference. Collectively, these data reveal the contribution of impaired ventral tegmental area function to social behaviors and identify mGluR1 modulation during postnatal development as a potential treatment strategy.
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PMID: 27273769
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Article (Published version) (3 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Les dysfonctions synaptiques du cerveau (971)
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BARISELLI, Sebastiano et al. SHANK3 controls maturation of social reward circuits in the VTA. In: Nature neuroscience, 2016, vol. 19, n° 7, p. 926-934. doi: 10.1038/nn.4319 https://archive-ouverte.unige.ch/unige:90712

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Deposited on : 2016-12-21

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