CYP17A1 Enzyme Activity Is Linked to Ambulatory Blood Pressure in a Family-Based Population Study

Ackermann, Daniel; Pruijm, Menno; Ponte, Belen; Guessous, Idris; Ehret, Georg Benedikt; Escher, Geneviève; Dick, Bernhard; Al-Alwan, Heba; Vuistiner, Philippe; Paccaud, Fred; Burnier, Michel; Pechere, Antoinette; Martin, Pierre-Yves; Vogt, Bruno; Mohaupt, Markus; Bochud, Murielle

doi:10.1093/ajh/hpv138

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Title		CYP17A1 Enzyme Activity Is Linked to Ambulatory Blood Pressure in a Family-Based Population Study
Authors		Ackermann, Daniel Pruijm, Menno Ponte, Belen Guessous, Idris Ehret, Georg Benedikt Escher, Geneviève Dick, Bernhard Al-Alwan, Heba Vuistiner, Philippe Paccaud, Fred Burnier, Michel Pechere, Antoinette Martin, Pierre-Yves Vogt, Bruno Mohaupt, Markus Bochud, Murielle show all authors [1 - 16]
Published in		American Journal of Hypertension. 2016, vol. 29, no. 4, p. 484-493
Abstract		Genome-wide association studies have linked CYP17A1 coding for the steroid hormone synthesizing enzyme 17α-hydroxylase (CYP17A1) to blood pressure (BP). We hypothesized that the genetic signal may translate into a correlation of ambulatory BP (ABP) with apparent CYP17A1 activity in a family-based population study and estimated the heritability of CYP17A1 activity.
Identifiers		DOI: 10.1093/ajh/hpv138 PMID: 26297028
Full text		Article (Published version) (2.1 MB) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires
Research groups		Traits génétiques complexes (901) Hypertension artérielle (128)
Citation (ISO format)		ACKERMANN, Daniel et al. CYP17A1 Enzyme Activity Is Linked to Ambulatory Blood Pressure in a Family-Based Population Study. In: American Journal of Hypertension, 2016, vol. 29, n° 4, p. 484-493. doi: 10.1093/ajh/hpv138 https://archive-ouverte.unige.ch/unige:90711