CYP17A1 Enzyme Activity Is Linked to Ambulatory Blood Pressure in a Family-Based Population Study

Ackermann, Daniel; Pruijm, Menno; Ponte, Belen; Guessous, Idris; Ehret, Georg Benedikt; Escher, Geneviève; Dick, Bernhard; Al-Alwan, Heba; Vuistiner, Philippe; Paccaud, Fred; Burnier, Michel; Pechere, Antoinette; Martin, Pierre-Yves; Vogt, Bruno; Mohaupt, Markus; Bochud, Murielle

doi:10.1093/ajh/hpv138

Scientific article

English

CYP17A1 Enzyme Activity Is Linked to Ambulatory Blood Pressure in a Family-Based Population Study

ContributorsAckermann, Daniel; Pruijm, Menno; Ponte, Belen; Guessous, Idris; Ehret, Georg Benedikt; Escher, Geneviève; Dick, Bernhard; Al-Alwan, Heba; Vuistiner, Philippe; Paccaud, Fred; Burnier, Michel; Pechere, Antoinette; Martin, Pierre-Yves; Vogt, Bruno; Mohaupt, Markus; Bochud, Murielle

Published inAmerican journal of hypertension, vol. 29, no. 4, p. 484-493

Publication date2016

Abstract

Genome-wide association studies have linked CYP17A1 coding for the steroid hormone synthesizing enzyme 17α-hydroxylase (CYP17A1) to blood pressure (BP). We hypothesized that the genetic signal may translate into a correlation of ambulatory BP (ABP) with apparent CYP17A1 activity in a family-based population study and estimated the heritability of CYP17A1 activity.

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Citation (ISO format)

ACKERMANN, Daniel et al. CYP17A1 Enzyme Activity Is Linked to Ambulatory Blood Pressure in a Family-Based Population Study. In: American journal of hypertension, 2016, vol. 29, n° 4, p. 484–493. doi: 10.1093/ajh/hpv138

Article (Published version)

Identifiers

PID : unige:90711
DOI : 10.1093/ajh/hpv138
PMID : 26297028

ISSN of the journal0895-7061

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CYP17A1 Enzyme Activity Is Linked to Ambulatory Blood Pressure in a Family-Based Population Study

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