Scientific article

Interference with HH-GLI signaling inhibits prostate cancer

Published inTrends in molecular medicine, vol. 11, no. 5, p. 199-203
Publication date2005

The Hedgehog-Gli (Hh-Gli) signaling pathway controls many aspects of tissue patterning, cell proliferation, differentiation and regeneration and regulates cell number in various organs. In adults, the Hh-Gli pathway remains active in a number of stem cells and regenerating tissues. Inappropriate and uncontrolled HH-GLI pathway activation has been demonstrated in a variety of human cancers. Three recent papers show that components of the pathway are expressed in human prostate tumors and, more importantly, that prostate cancers depend on sustained HH-GLI signaling. These data raise the possibility of a new therapeutic approach to treat this often lethal disease.

  • Animals
  • Antibodies/therapeutic use
  • Cell Differentiation/drug effects/physiology
  • Hedgehog Proteins
  • Humans
  • Male
  • Prostatic Neoplasms/drug therapy/ metabolism
  • RNA, Small Interfering/therapeutic use
  • Signal Transduction/drug effects/ physiology
  • Stem Cells/physiology
  • Trans-Activators/antagonists & inhibitors/ metabolism
  • Transcription Factors/ metabolism
  • Veratrum Alkaloids/therapeutic use
Citation (ISO format)
STECCA, Barbara, MAS, Christophe, RUIZ ALTABA, Ariel. Interference with HH-GLI signaling inhibits prostate cancer. In: Trends in molecular medicine, 2005, vol. 11, n° 5, p. 199–203. doi: 10.1016/j.molmed.2005.03.004
Main files (1)
ISSN of the journal1471-4914

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