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Interference with HH-GLI signaling inhibits prostate cancer

Stecca, Barbara
Published in Trends in Molecular Medicine. 2005, vol. 11, no. 5, p. 199-203
Abstract The Hedgehog-Gli (Hh-Gli) signaling pathway controls many aspects of tissue patterning, cell proliferation, differentiation and regeneration and regulates cell number in various organs. In adults, the Hh-Gli pathway remains active in a number of stem cells and regenerating tissues. Inappropriate and uncontrolled HH-GLI pathway activation has been demonstrated in a variety of human cancers. Three recent papers show that components of the pathway are expressed in human prostate tumors and, more importantly, that prostate cancers depend on sustained HH-GLI signaling. These data raise the possibility of a new therapeutic approach to treat this often lethal disease.
Keywords AnimalsAntibodies/therapeutic useCell Differentiation/drug effects/physiologyHedgehog ProteinsHumansMaleProstatic Neoplasms/drug therapy/ metabolismRNA, Small Interfering/therapeutic useSignal Transduction/drug effects/ physiologyStem Cells/physiologyTrans-Activators/antagonists & inhibitors/ metabolismTranscription Factors/ metabolismVeratrum Alkaloids/therapeutic use
PMID: 15882606
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STECCA, Barbara, MAS, Christophe, RUIZ ALTABA, Ariel. Interference with HH-GLI signaling inhibits prostate cancer. In: Trends in Molecular Medicine, 2005, vol. 11, n° 5, p. 199-203. https://archive-ouverte.unige.ch/unige:9039

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Deposited on : 2010-07-12

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