Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways
Contributeurs/tricesStecca, Barbara; Mas, Christophe; Clement, Virginie; Zbinden, Marie; Correa, Rafael; Piguet, Vincent; Beermann, Friedrich; Ruiz Altaba, Ariel
Publié dansProceedings of the National Academy of Sciences of the United States of America, vol. 104, no. 14, p. 5895-5900
Date de publication2007
Résumé
Mots-clés
- Animals
- COS Cells
- Cell Proliferation
- Cells, Cultured
- Cercopithecus aethiops
- Fibroblasts/metabolism
- Foreskin/cytology
- Gene Expression Regulation, Neoplastic
- Hedgehog Proteins/ physiology
- Humans
- Male
- Melanocytes/metabolism/physiology
- Melanoma/genetics/ metabolism/physiopathology
- Melanoma, Experimental/genetics/metabolism/physiopathology
- Mice
- Mice, Nude
- Mice, Transgenic
- Mitogen-Activated Protein Kinase Kinases/ metabolism
- Models, Biological
- Neoplasm Transplantation
- Proto-Oncogene Proteins c-akt/ metabolism
- Signal Transduction
- Transcription Factors/ physiology
- Transplantation, Heterologous
Structure d'affiliation
Citation (format ISO)
STECCA, Barbara et al. Melanomas require HEDGEHOG-GLI signaling regulated by interactions between GLI1 and the RAS-MEK/AKT pathways. In: Proceedings of the National Academy of Sciences of the United States of America, 2007, vol. 104, n° 14, p. 5895–5900. doi: 10.1073/pnas.0700776104
Fichiers principaux (1)
Article
Identifiants
- PID : unige:9038
- DOI : 10.1073/pnas.0700776104
- PMID : 17392427
ISSN du journal0027-8424