The choice of the noninferiority margin in clinical trials was driven by baseline risk, type of primary outcome, and benefits of new treatment

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Title		The choice of the noninferiority margin in clinical trials was driven by baseline risk, type of primary outcome, and benefits of new treatment
Authors		Gayet-Ageron, Angèle Agoritsas, Thomas Rudaz, Sandrine Courvoisier, Delphine Perneger, Thomas
Published in		Journal of Clinical Epidemiology. 2015, vol. 68, no. 10, p. 1144-1151
Abstract		To explore characteristics of clinical trials that influence the choice of the noninferiority margin (NIM) when planning the trial.
Keywords		Adult — Confidence Intervals — Cross-Sectional Studies — Female — Humans — Male — Middle Aged — Models, Statistical — Randomized Controlled Trials as Topic — Research Personnel/psychology — Sample Size — Surveys and Questionnaires — Treatment Outcome
Identifiers		DOI: 10.1016/j.jclinepi.2015.01.017 PMID: 25716902
Full text		Article (Published version) (210 Kb) - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de réadaptation et gériatrie Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires
Research group		Epidémiologie clinique (115)
Citation (ISO format)		GAYET-AGERON, Angèle et al. The choice of the noninferiority margin in clinical trials was driven by baseline risk, type of primary outcome, and benefits of new treatment. In: Journal of Clinical Epidemiology, 2015, vol. 68, n° 10, p. 1144-1151. doi: 10.1016/j.jclinepi.2015.01.017 https://archive-ouverte.unige.ch/unige:90339