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Scientific article
English

Temperature dependence of human gastrocnemius pH and high-energy phosphate concentration by noninvasive techniques

Published inMagnetic resonance in medicine, vol. 43, no. 4, p. 611-614
Publication date2000
Abstract

It is well established that ADP is an important regulator of the oxidative phosphorylation in the mitochondria. Thus, by means of noninvasive techniques it is demonstrated that the relationship between O(2) consumption of the human gastrocnemius at rest and its temperature is likely determined by at least two factors: 1) the modulation of the rate of the chemical reactions imposed by the "physical" temperature-effect; 2) the influence of temperature-induced ADP concentration changes ( approximately 0.83 microM degrees C(-1)) on oxidative phosphorylation. ADP was assessed by applying the temperature-corrected Lohmann equilibrium equation. PCr and ATP were found to increase, with decreasing temperature (-0.54+/-0.05 and -0.17+/-mM degrees C(-1), respectively), while pH varies following the alpha-stat hypothesis (-0.016+/-0.001 pH degrees C(-1)). These findings should be of value when dealing with muscle physiology in extreme environments or clinical applications of hypothermia.

Keywords
  • Adenosine Diphosphate/metabolism
  • Humans
  • Hydrogen-Ion Concentration
  • Magnetic Resonance Spectroscopy
  • Models, Biological
  • Muscle, Skeletal/metabolism
  • Nonlinear Dynamics
  • Oxygen Consumption
  • Sensitivity and Specificity
  • Temperature
Citation (ISO format)
BINZONI, Tiziano et al. Temperature dependence of human gastrocnemius pH and high-energy phosphate concentration by noninvasive techniques. In: Magnetic resonance in medicine, 2000, vol. 43, n° 4, p. 611–614.
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Article (Published version)
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ISSN of the journal0740-3194
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