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Quantitative variability of 342 plasma proteins in a human twin population

Liu, Yansheng
Collins, Ben C
Gillet, Ludovic C J
Blum, Lorenz C
Cheng, Lin-Yang
Vitek, Olga
Mouritsen, Jeppe
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Published in Molecular systems biology. 2015, vol. 11, no. 1, 786
Abstract The degree and the origins of quantitative variability of most human plasma proteins are largely unknown. Because the twin study design provides a natural opportunity to estimate the relative contribution of heritability and environment to different traits in human population, we applied here the highly accurate and reproducible SWATH mass spectrometry technique to quantify 1,904 peptides defining 342 unique plasma proteins in 232 plasma samples collected longitudinally from pairs of monozygotic and dizygotic twins at intervals of 2-7 years, and proportioned the observed total quantitative variability to its root causes, genes, and environmental and longitudinal factors. The data indicate that different proteins show vastly different patterns of abundance variability among humans and that genetic control and longitudinal variation affect protein levels and biological processes to different degrees. The data further strongly suggest that the plasma concentrations of clinical biomarkers need to be calibrated against genetic and temporal factors. Moreover, we identified 13 cis-SNPs significantly influencing the level of specific plasma proteins. These results therefore have immediate implications for the effective design of blood-based biomarker studies.
Keywords AdultAgedBlood Proteins/geneticsComputational BiologyDatabases, GeneticEuropean Continental Ancestry GroupEvaluation Studies as TopicFemaleGenetic MarkersHumansLinear ModelsLongitudinal StudiesMiddle AgedPolymorphism, Single NucleotideProteomicsQuantitative Trait LociTwins, Dizygotic/geneticsTwins, Monozygotic/genetics
PMID: 25652787
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Article (Published version) (2.2 MB) - public document Free access
Research group Population Genomics and Genetics of Complex Traits (892)
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LIU, Yansheng et al. Quantitative variability of 342 plasma proteins in a human twin population. In: Molecular systems biology, 2015, vol. 11, n° 1, p. 786. doi: 10.15252/msb.20145728 https://archive-ouverte.unige.ch/unige:90261

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Deposited on : 2016-12-13

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