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Scientific article
English

Assessing allele-specific expression across multiple tissues from RNA-seq read data

Published inBioinformatics, vol. 31, no. 15, p. 2497-2504
Publication date2015
Abstract

RNA sequencing enables allele-specific expression (ASE) studies that complement standard genotype expression studies for common variants and, importantly, also allow measuring the regulatory impact of rare variants. The Genotype-Tissue Expression (GTEx) project is collecting RNA-seq data on multiple tissues of a same set of individuals and novel methods are required for the analysis of these data.

Keywords
  • Alleles
  • Extracellular Matrix Proteins/genetics/metabolism
  • High-Throughput Nucleotide Sequencing/methods
  • Humans
  • Lipoid Proteinosis of Urbach and Wiethe/genetics/metabolism
  • Organ Specificity
  • Polymorphism, Single Nucleotide/genetics
  • Protein Isoforms
  • RNA/analysis/genetics
Citation (ISO format)
PIRINEN, Matti et al. Assessing allele-specific expression across multiple tissues from RNA-seq read data. In: Bioinformatics, 2015, vol. 31, n° 15, p. 2497–2504. doi: 10.1093/bioinformatics/btv074
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ISSN of the journal1367-4803
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