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Neurofeedback Tunes Scale-Free Dynamics in Spontaneous Brain Activity

Frewen, P.
Théberge, J.
Kluetsch, R.
Mueller, A.
Candrian, G.
Jetly, R.
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Published in Cerebral cortex. 2016
Abstract Brain oscillations exhibit long-range temporal correlations (LRTCs), which reflect the regularity of their fluctuations: low values representing more random (decorrelated) while high values more persistent (correlated) dynamics. LRTCs constitute supporting evidence that the brain operates near criticality, a state where neuronal activities are balanced between order and randomness. Here, healthy adults used closed-loop brain training (neurofeedback, NFB) to reduce the amplitude of alpha oscillations, producing a significant increase in spontaneous LRTCs post-training. This effect was reproduced in patients with post-traumatic stress disorder, where abnormally random dynamics were reversed by NFB, correlating with significant improvements in hyperarousal. Notably, regions manifesting abnormally low LRTCs (i.e., excessive randomness) normalized toward healthy population levels, consistent with theoretical predictions about self-organized criticality. Hence, when exposed to appropriate training, spontaneous cortical activity reveals a residual capacity for "self-tuning" its own temporal complexity, despite manifesting the abnormal dynamics seen in individuals with psychiatric disorder. Lastly, we observed an inverse-U relationship between strength of LRTC and oscillation amplitude, suggesting a breakdown of long-range dependence at high/low synchronization extremes, in line with recent computational models. Together, our findings offer a broader mechanistic framework for motivating research and clinical applications of NFB, encompassing disorders with perturbed LRTCs.
Keywords neurofeedbackEEGPTSDHurst exponentscale-free dynamics
PMID: 27620975
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Article (Published version) (1 MB) - public document Free access
Research group Mécanismes cérébraux du comportement et des fonctions cognitives (701)
European Commission: BRIDGE COFUND
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ROS, Tomas et al. Neurofeedback Tunes Scale-Free Dynamics in Spontaneous Brain Activity. In: Cerebral cortex, 2016. doi: 10.1093/cercor/bhw285 https://archive-ouverte.unige.ch/unige:90238

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Deposited on : 2016-12-09

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