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Chimiothérapie de maintenance : futile ou utile ?

Published in Revue médicale suisse. 2015, vol. 11, no. 475, p. 1103-1107
Abstract In incurable diseases, maintenance therapy aims to prolong the response achieved through induction. The goal is to delay disease progression, thus prolonging survival. Two maintenance modalities are used. The first, called continuation maintenance, consists of continuing the same agent used in the initial treatment. The second, called switch-maintenance, introduces an early second line drug immediately after induction. Proving the superiority of a maintenance strategy implies a better outcome with the maintenance compared to the same therapeutic agent used upon disease progression. This benefit may be observed in terms of overall survival and/or quality of life.
Keywords Adenocarcinoma/drug therapy/pathologyAgedAntibodies, Monoclonal, Murine-Derived/therapeutic useAntineoplastic Combined Chemotherapy Protocols/therapeutic useCisplatin/administration & dosageGlutamates/administration & dosageGuanine/administration & dosage/analogs & derivativesHumansLung Neoplasms/drug therapy/pathologyLymphoma, Follicular/drug therapy/pathologyMaintenance Chemotherapy/psychology/utilizationMaleMedical FutilityNeoplasms/drug therapyPemetrexedQuality of LifeRituximab
PMID: 26152084
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Research group Immunothérapie des cancers (42)
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FRIEDLAENDER, Alex, FERNANDEZ, Eugenio, DIETRICH, Pierre-Yves. Chimiothérapie de maintenance : futile ou utile ?. In: Revue médicale suisse, 2015, vol. 11, n° 475, p. 1103-1107. https://archive-ouverte.unige.ch/unige:90182

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Deposited on : 2016-12-08

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