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Title

TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes

Authors
Sanvito, F.
Nichols, A.
Published in Biochemical and Biophysical Research Communications. 1995, vol. 217, no. 3, p. 1279-1286
Abstract We have generated transgenic mice overexpressing TGF-beta 1 in pancreatic beta cells. This resulted in massive fibrosis of the pancreas; in adult mice, most of the acini were replaced by fibrotic and adipose tissues. A conspicuous disorganization of the islets of Langerhans was also observed; however, the number of beta cells was not decreased and the mice were normoglycemic. Backcrossing to transgenic mice overexpressing TNF-alpha in their islet beta cells (which also remain normoglycemic, (1)) yielded double transgenics, most of which became diabetic by the age of 4 months; histological analysis revealed a dramatic decrease in insulin-containing beta cells.
Keywords Amylases/metabolismAnimalsBase SequenceChronic DiseaseDNA Primers/chemistryDiabetes Mellitus, Type 1/ etiologyInsulin/metabolismIslets of Langerhans/metabolismMiceMice, TransgenicMolecular Sequence DataPancreas/metabolismPancreatitis/ etiologyTransforming Growth Factor beta/ metabolismTumor Necrosis Factor-alpha/ metabolism
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PMID: 8554587
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SANVITO, F. et al. TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes. In: Biochemical and Biophysical Research Communications, 1995, vol. 217, n° 3, p. 1279-1286. https://archive-ouverte.unige.ch/unige:9015

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Deposited on : 2010-07-12

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