TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes

Sanvito, F.; Nichols, A.; Herrera, Pedro Luis; Huarte, Joachim; Wohlwend, Annelise Isabelle; Vassalli, Jean-Dominique; Orci, Lelio

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Title		TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes
Authors		Sanvito, F. Nichols, A. Herrera, Pedro Luis Huarte, Joachim Wohlwend, Annelise Isabelle Vassalli, Jean-Dominique Orci, Lelio
Published in		Biochemical and Biophysical Research Communications. 1995, vol. 217, no. 3, p. 1279-1286
Abstract		We have generated transgenic mice overexpressing TGF-beta 1 in pancreatic beta cells. This resulted in massive fibrosis of the pancreas; in adult mice, most of the acini were replaced by fibrotic and adipose tissues. A conspicuous disorganization of the islets of Langerhans was also observed; however, the number of beta cells was not decreased and the mice were normoglycemic. Backcrossing to transgenic mice overexpressing TNF-alpha in their islet beta cells (which also remain normoglycemic, (1)) yielded double transgenics, most of which became diabetic by the age of 4 months; histological analysis revealed a dramatic decrease in insulin-containing beta cells.
Keywords		Amylases/metabolism — Animals — Base Sequence — Chronic Disease — DNA Primers/chemistry — Diabetes Mellitus, Type 1/ etiology — Insulin/metabolism — Islets of Langerhans/metabolism — Mice — Mice, Transgenic — Molecular Sequence Data — Pancreas/metabolism — Pancreatitis/ etiology — Transforming Growth Factor beta/ metabolism — Tumor Necrosis Factor-alpha/ metabolism
Identifiers		DOI: 10.1006/bbrc.1995.2906 PMID: 8554587
Full text		Article - Limited access to UNIGE
Structures		Faculté de médecine / Section de médecine clinique / Département de médecine interne des spécialités
Citation (ISO format)		SANVITO, F. et al. TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes. In: Biochemical and Biophysical Research Communications, 1995, vol. 217, n° 3, p. 1279-1286. https://archive-ouverte.unige.ch/unige:9015

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TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes