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Scientific article
English

TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes

Published inBiochemical and biophysical research communications, vol. 217, no. 3, p. 1279-1286
Publication date1995
Abstract

We have generated transgenic mice overexpressing TGF-beta 1 in pancreatic beta cells. This resulted in massive fibrosis of the pancreas; in adult mice, most of the acini were replaced by fibrotic and adipose tissues. A conspicuous disorganization of the islets of Langerhans was also observed; however, the number of beta cells was not decreased and the mice were normoglycemic. Backcrossing to transgenic mice overexpressing TNF-alpha in their islet beta cells (which also remain normoglycemic, (1)) yielded double transgenics, most of which became diabetic by the age of 4 months; histological analysis revealed a dramatic decrease in insulin-containing beta cells.

Keywords
  • Amylases/metabolism
  • Animals
  • Base Sequence
  • Chronic Disease
  • DNA Primers/chemistry
  • Diabetes Mellitus, Type 1/ etiology
  • Insulin/metabolism
  • Islets of Langerhans/metabolism
  • Mice
  • Mice, Transgenic
  • Molecular Sequence Data
  • Pancreas/metabolism
  • Pancreatitis/ etiology
  • Transforming Growth Factor beta/ metabolism
  • Tumor Necrosis Factor-alpha/ metabolism
Citation (ISO format)
SANVITO, F. et al. TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes. In: Biochemical and biophysical research communications, 1995, vol. 217, n° 3, p. 1279–1286. doi: 10.1006/bbrc.1995.2906
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ISSN of the journal0006-291X
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