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Drug-induced epidermolysis bullosa acquisita with antibodies to type VII collagen

Friedli, André
Woodley, David T
Published in Journal of the American Academy of Dermatology. 2002, vol. 46, no. Suppl. 5, p. S161-S164-4
Abstract We describe a 73-year-old patient who had a subepidermal bullous eruption develop after a course of antibiotics, including vancomycin. The patient had deposits of IgA and IgG in the cutaneous basement membrane zone that were located on the dermal side of 1 M NaCl-treated autologous skin. By an enzyme-linked immunosorbent assay, the patient was found to have circulating IgG antibodies directed against type VII collagen, the target antigen of epidermolysis bullosa acquisita. Our observation expands the spectrum of immune-mediated subepidermal bullous skin eruptions precipitated by drugs and lends support to the idea that a subset of these cases represents an unusual variant of drug-triggered epidermolysis bullosa acquisita.
Keywords Adenocarcinoma/drug therapy/surgeryAgedAutoantibodies/immunologyBiopsy, NeedleCollagen/immunologyEnzyme-Linked Immunosorbent AssayEpidermolysis Bullosa Acquisita/chemically induced/immunology/pathologyFluorescent Antibody Technique, DirectFollow-Up StudiesGentamicins/administration & dosage/adverse effectsHumansInfusions, IntravenousPancreatic Neoplasms/drug therapy/surgerySurgical Wound Infection/prevention & controlVancomycin/administration & dosage/adverse effects
PMID: 12004302
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Research group Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
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DELBALDO, Catherine Suzanne et al. Drug-induced epidermolysis bullosa acquisita with antibodies to type VII collagen. In: Journal of the American Academy of Dermatology, 2002, vol. 46, n° Suppl. 5, p. S161-S164-4. https://archive-ouverte.unige.ch/unige:90112

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Deposited on : 2016-12-08

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