Drug-induced epidermolysis bullosa acquisita with antibodies to type VII collagen

Article Article scientifique Rapport de cas Drug-induced epidermolysis bullosa acquisita with antibodies to type VII collagen eng 2002 author Delbaldo Catherine Suzanne 34830 author Chen Meilin 96639 author Friedli André author Prins Christa 526940 author Desmeules Jules Alexandre 73542 author Saurat Jean-Hilaire 21995 author Woodley David T author Borradori Luca 120287 S161-S164-164 10.1067/mjd.2002.107774 12004302 0190-9622 We describe a 73-year-old patient who had a subepidermal bullous eruption develop after a course of antibiotics, including vancomycin. The patient had deposits of IgA and IgG in the cutaneous basement membrane zone that were located on the dermal side of 1 M NaCl-treated autologous skin. By an enzyme-linked immunosorbent assay, the patient was found to have circulating IgG antibodies directed against type VII collagen, the target antigen of epidermolysis bullosa acquisita. Our observation expands the spectrum of immune-mediated subepidermal bullous skin eruptions precipitated by drugs and lends support to the idea that a subset of these cases represents an unusual variant of drug-triggered epidermolysis bullosa acquisita. Adenocarcinoma/drug therapy/surgery Aged Autoantibodies/immunology Biopsy, Needle Collagen/immunology Enzyme-Linked Immunosorbent Assay Epidermolysis Bullosa Acquisita/chemically induced/immunology/pathology Fluorescent Antibody Technique, Direct Follow-Up Studies Gentamicins/administration & dosage/adverse effects Humans Infusions, Intravenous Pancreatic Neoplasms/drug therapy/surgery Surgical Wound Infection/prevention & control Vancomycin/administration & dosage/adverse effects Dewey 616 Dewey 617 56 Département de médecine 221 63 Département d'anesthésiologie, pharmacologie, soins intensifs et urgences 229 false 302 Groupe Desmeules Jules (pharmacologie/toxicologie) 567 Journal of the American Academy of Dermatology 46 Suppl. 5 b919976c-4383-4add-b2aa-0773a0b1b46c Article (Published version) Restricted 1-s2.0-S0190962202263239-main.pdf 162136 application/pdf restrictedAccess Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences

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Drug-induced epidermolysis bullosa acquisita with antibodies to type VII collagen	Journal of the American Academy of Dermatology			2002	529	0

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Chen, Meilin