Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer

Sanchez, Pilar; Clement, Virginie; Ruiz Altaba, Ariel

doi:10.1158/0008-5472.CAN-05-0439

Scientific article

English

Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer

ContributorsSanchez, Pilar; Clement, Virginie; Ruiz Altaba, Ariel

Published inCancer research, vol. 65, no. 8, p. 2990-2992

Publication date2005

Abstract

The Hedgehog-GLI signaling pathway is important in animal development and tumorigenesis. Recent findings indicate that the growth and survival of human prostate cancer cells rely upon sustained signaling from the Hedgehog-GLI pathway. These findings have prompted a novel rational strategy for therapeutic treatment of prostate tumors, including metastatic tumors.

Keywords

Animals
Genes, Tumor Suppressor
Hedgehog Proteins
Humans
Male
Membrane Proteins/biosynthesis/genetics/ metabolism
Oncogene Proteins/biosynthesis/genetics/ metabolism
Prostatic Neoplasms/genetics/ metabolism
Receptors, Cell Surface/biosynthesis/genetics/ metabolism
Signal Transduction
Trans-Activators/biosynthesis/genetics/ metabolism
Transcription Factors/biosynthesis/genetics/ metabolism

Affiliation entities

Faculté de médecine / Section de médecine clinique / Département de médecine

Citation (ISO format)

SANCHEZ, Pilar, CLEMENT, Virginie, RUIZ ALTABA, Ariel. Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer. In: Cancer research, 2005, vol. 65, n° 8, p. 2990–2992. doi: 10.1158/0008-5472.CAN-05-0439

Article

Identifiers

PID : unige:9011
DOI : 10.1158/0008-5472.CAN-05-0439
PMID : 15833820

Additional URL for this publicationhttp://cancerres.aacrjournals.org/cgi/reprint/65/8/2990.pdf

Journal ISSN0008-5472

567views

0downloads

Creation12/07/2010 11:59:53

First validation12/07/2010 11:59:53

Update time14/03/2023 15:52:46

Status update14/03/2023 15:52:46

Last indexation29/10/2024 15:56:48

Archive ouverte UNIGE

Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer

Technical informations