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Scientific article
English

Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer

Published inCancer research, vol. 65, no. 8, p. 2990-2992
Publication date2005
Abstract

The Hedgehog-GLI signaling pathway is important in animal development and tumorigenesis. Recent findings indicate that the growth and survival of human prostate cancer cells rely upon sustained signaling from the Hedgehog-GLI pathway. These findings have prompted a novel rational strategy for therapeutic treatment of prostate tumors, including metastatic tumors.

Keywords
  • Animals
  • Genes, Tumor Suppressor
  • Hedgehog Proteins
  • Humans
  • Male
  • Membrane Proteins/biosynthesis/genetics/ metabolism
  • Oncogene Proteins/biosynthesis/genetics/ metabolism
  • Prostatic Neoplasms/genetics/ metabolism
  • Receptors, Cell Surface/biosynthesis/genetics/ metabolism
  • Signal Transduction
  • Trans-Activators/biosynthesis/genetics/ metabolism
  • Transcription Factors/biosynthesis/genetics/ metabolism
Citation (ISO format)
SANCHEZ, Pilar, CLEMENT, Virginie, RUIZ ALTABA, Ariel. Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer. In: Cancer research, 2005, vol. 65, n° 8, p. 2990–2992. doi: 10.1158/0008-5472.CAN-05-0439
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ISSN of the journal0008-5472
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