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Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer

Sanchez, Pilar
Published in Cancer Research. 2005, vol. 65, no. 8, p. 2990-2992
Abstract The Hedgehog-GLI signaling pathway is important in animal development and tumorigenesis. Recent findings indicate that the growth and survival of human prostate cancer cells rely upon sustained signaling from the Hedgehog-GLI pathway. These findings have prompted a novel rational strategy for therapeutic treatment of prostate tumors, including metastatic tumors.
Keywords AnimalsGenes, Tumor SuppressorHedgehog ProteinsHumansMaleMembrane Proteins/biosynthesis/genetics/ metabolismOncogene Proteins/biosynthesis/genetics/ metabolismProstatic Neoplasms/genetics/ metabolismReceptors, Cell Surface/biosynthesis/genetics/ metabolismSignal TransductionTrans-Activators/biosynthesis/genetics/ metabolismTranscription Factors/biosynthesis/genetics/ metabolism
PMID: 15833820
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SANCHEZ, Pilar, CLEMENT, Virginie, RUIZ ALTABA, Ariel. Therapeutic targeting of the Hedgehog-GLI pathway in prostate cancer. In: Cancer Research, 2005, vol. 65, n° 8, p. 2990-2992. doi: 10.1158/0008-5472.CAN-05-0439 https://archive-ouverte.unige.ch/unige:9011

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Deposited on : 2010-07-12

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