Drug-induced long QT syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors

Ehret, Georg Benedikt; Voide, Cathy; Gex-Fabry, Marianne; Chabert, Jocelyne; Shah, Dipen; Broers, Barbara; Piguet, Valérie; Musset, Thierry; Gaspoz, Jean-Michel; Perrier, Arnaud; Dayer, Pierre; Desmeules, Jules Alexandre

doi:10.1001/archinte.166.12.1280

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Title		Drug-induced long QT syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors
Authors		Ehret, Georg Benedikt Voide, Cathy Gex-Fabry, Marianne Chabert, Jocelyne Shah, Dipen Broers, Barbara Piguet, Valérie Musset, Thierry Gaspoz, Jean-Michel Perrier, Arnaud Dayer, Pierre Desmeules, Jules Alexandre show all authors [1 - 12]
Published in		Archives of Internal Medicine. 2006, vol. 166, no. 12, p. 1280-1287
Abstract		Drug-induced long QT syndrome is a serious adverse drug reaction. Methadone prolongs the QT interval in vitro in a dose-dependent manner. In the inpatient setting, the frequency of QT interval prolongation with methadone treatment, its dose dependence, and the importance of cofactors such as drug-drug interactions remain unknown.
Keywords		Adolescent — Adult — Electrocardiography — Female — Follow-Up Studies — Humans — Long QT Syndrome/chemically induced/epidemiology/physiopathology — Male — Methadone/adverse effects — Middle Aged — Narcotics/adverse effects — Prevalence — Retrospective Studies — Risk Factors — Substance Abuse, Intravenous/rehabilitation
Identifiers		DOI: 10.1001/archinte.166.12.1280 PMID: 16801510
Full text		Article (Published version) (239 Kb) - Free access
Structures		Faculté de médecine / Section de médecine clinique / Département de psychiatrie Faculté de médecine / Section de médecine clinique / Département de médecine Faculté de médecine / Section de médecine clinique / Département d'anesthésiologie, pharmacologie, soins intensifs et urgences Faculté de médecine / Section de médecine clinique / Département de santé et médecine communautaires
Research group		Groupe Desmeules Jules (pharmacologie/toxicologie) (567)
Citation (ISO format)		EHRET, Georg Benedikt et al. Drug-induced long QT syndrome in injection drug users receiving methadone: high frequency in hospitalized patients and risk factors. In: Archives of Internal Medicine, 2006, vol. 166, n° 12, p. 1280-1287. doi: 10.1001/archinte.166.12.1280 https://archive-ouverte.unige.ch/unige:90104