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The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells

Quoix, Nicolas
Cheng-Xue, Rui
Guiot, Yves
Henquin, J. C.
Gilon, Patrick
Published in FEBS Letters. 2007, vol. 581, no. 22, p. 4235-4240
Abstract The control of glucagon secretion by pancreatic alpha-cells is poorly understood, largely because of the difficulty to recognize living alpha-cells. We describe a new mouse model, referred to as GluCre-ROSA26EYFP (or GYY), allowing easy alpha-cell identification because of specific expression of EYFP. GYY mice displayed normal glycemic control during a fasting/refeeding test or intraperitoneal insulin injection. Glucagon secretion by isolated islets was normally inhibited by glucose and stimulated by adrenaline. [Ca(2+)](c) responses to arginine, adrenaline, diazoxide and tolbutamide, were similar in GYY and control mice. Hence, this new mouse model is a reliable and powerful tool to specifically study alpha-cells.
Keywords AnimalsBacterial Proteins/ metabolismCalcium/metabolismCell SurvivalGlucagon/ metabolism/secretionGlucagon-Secreting Cells/ cytologyInsulin/secretionInsulin-Secreting Cells/cytologyIntegrases/ metabolismLuminescent Proteins/ metabolismMiceMice, TransgenicModels, AnimalOrgan Specificity
PMID: 17706201
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Research group Types cellulaires pancréatiques pendant l'ontogénèse (522)
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QUOIX, Nicolas et al. The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells. In: FEBS letters, 2007, vol. 581, n° 22, p. 4235-4240. doi: 10.1016/j.febslet.2007.07.068 https://archive-ouverte.unige.ch/unige:8975

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Deposited on : 2010-07-12

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