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Mitochondrial Flashes: Dump Superoxide and Dance with Protons Now

Contributors

Demaurex, Nicolas; Schwarzländer, Markus

Published in

Antioxidants & redox signaling, vol. 25, no. 9, p. 550-551

Publication date

2016

Abstract

Transient changes in the physiology of individual mitochondria have recently drawn much interest. The use of a circular permuted yellow fluorescent protein (cpYFP) to monitor mitochondrial flashes and their interpretation as superoxide bursts has added confusion, however. Reviewing mitochondrial flashes in this Forum, Wang et al. again deem cpYFP to be a specific and reversible superoxide indicator, dismissing evidence that purified cpYFP is insensitive to superoxide. This interpretation lacks reproducible evidence and conflicts with the parsimony principle. We offer a constructive, transparent pathway to reach definitive clarification of contradictory reports. Antioxid. Redox Signal. 25, 550-551.

UNIGE affiliation entities

UNIGE research groups

Funding

Citation (ISO format)

DEMAUREX, Nicolas, SCHWARZLÄNDER, Markus. Mitochondrial Flashes: Dump Superoxide and Dance with Protons Now. In: Antioxidants & redox signaling, 2016, vol. 25, n° 9, p. 550–551. doi: 10.1089/ars.2016.6819

Main files (1)

Article (Published version)

Identifiers

Journal ISSN

1523-0864
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440downloads

Technical informations

Creation

06/10/2016 16:00:00

First validation

06/10/2016 16:00:00

Update

20/01/2025 10:06:58

Status update

20/01/2025 10:06:58

Last indexation

20/01/2025 10:16:29
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