Scientific article
Open access

Mitochondrial Flashes: Dump Superoxide and Dance with Protons Now

Published inAntioxidants & redox signaling, vol. 25, no. 9, p. 550-551
Publication date2016

Transient changes in the physiology of individual mitochondria have recently drawn much interest. The use of a circular permuted yellow fluorescent protein (cpYFP) to monitor mitochondrial flashes and their interpretation as superoxide bursts has added confusion, however. Reviewing mitochondrial flashes in this Forum, Wang et al. again deem cpYFP to be a specific and reversible superoxide indicator, dismissing evidence that purified cpYFP is insensitive to superoxide. This interpretation lacks reproducible evidence and conflicts with the parsimony principle. We offer a constructive, transparent pathway to reach definitive clarification of contradictory reports. Antioxid. Redox Signal. 25, 550-551.

Citation (ISO format)
DEMAUREX, Nicolas, SCHWARZLÄNDER, Markus. Mitochondrial Flashes: Dump Superoxide and Dance with Protons Now. In: Antioxidants & redox signaling, 2016, vol. 25, n° 9, p. 550–551. doi: 10.1089/ars.2016.6819
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Article (Published version)
ISSN of the journal1523-0864

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