Scientific article
Open access

Beta-cell mitochondrial carriers and the diabetogenic stress response

Published inBiochimica et biophysica acta, vol. 1863, no. 10, p. 2540-2549
Publication date2016

Mitochondria play a central role in pancreatic beta-cells by coupling metabolism of the secretagogue glucose to distal events of regulated insulin exocytosis. This process requires transports of both metabolites and nucleotides in and out of the mitochondria. The molecular identification of mitochondrial carriers and their respective contribution to beta-cell function have been uncovered only recently. In type 2 diabetes, mitochondrial dysfunction is an early event and may precipitate beta-cell loss. Under diabetogenic conditions, characterized by glucotoxicity and lipotoxicity, the expression profile of mitochondrial carriers is selectively modified. This review describes the role of mitochondrial carriers in beta-cells and the selective changes in response to glucolipotoxicity. In particular, we discuss the importance of the transfer of metabolites (pyruvate, citrate, malate, and glutamate) and nucleotides (ATP, NADH, NADPH) for beta-cell function and dysfunction. This article is part of a Special Issue entitled: Mitochondrial Channels edited by Pierre Sonveaux, Pierre Maechler and Jean-Claude Martinou.

Citation (ISO format)
BRUN, Thierry, MAECHLER, Pierre. Beta-cell mitochondrial carriers and the diabetogenic stress response. In: Biochimica et biophysica acta, 2016, vol. 1863, n° 10, p. 2540–2549. doi: 10.1016/j.bbamcr.2016.03.012
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Article (Published version)
ISSN of the journal0006-3002

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Creation10/04/2016 11:42:00 AM
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