en
Scientific article
English

Effect of estetrol on Beta-Endorphin level in female rats

Published inSteroids, vol. 95, p. 104-110
Publication date2015
Abstract

Estetrol (E4), a naturally occurring estrogen produced exclusively by human fetal liver, is currently being evaluated for potential use in contraception and menopausal care in humans. The present study was designed to profile E4 effects on the central nervous system, to assess the in vivo effects of E4 administration on Beta-Endorphin (β-END) release in specific brain structures and to evaluate whether E4 has synergic or antagonistic effects on estradiol-mediated β-END synthesis.

Keywords
  • Animals
  • Dose-Response Relationship, Drug
  • Drug Antagonism
  • Drug Synergism
  • Estetrol/pharmacology
  • Estradiol/analogs & derivatives/pharmacology
  • Female
  • Ovariectomy
  • Rats
  • Rats, Wistar
  • beta-Endorphin/metabolism
Citation (ISO format)
PLUCHINO, Nicola et al. Effect of estetrol on Beta-Endorphin level in female rats. In: Steroids, 2015, vol. 95, p. 104–110. doi: 10.1016/j.steroids.2015.01.003
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Article (Published version)
accessLevelRestricted
Identifiers
ISSN of the journal0039-128X
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