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Title

Effect of estetrol on Beta-Endorphin level in female rats

Authors
Casarosa, E
Freschi, L
Genazzani, A R
Published in Steroids. 2015, vol. 95, p. 104-110
Abstract Estetrol (E4), a naturally occurring estrogen produced exclusively by human fetal liver, is currently being evaluated for potential use in contraception and menopausal care in humans. The present study was designed to profile E4 effects on the central nervous system, to assess the in vivo effects of E4 administration on Beta-Endorphin (β-END) release in specific brain structures and to evaluate whether E4 has synergic or antagonistic effects on estradiol-mediated β-END synthesis.
Keywords AnimalsDose-Response Relationship, DrugDrug AntagonismDrug SynergismEstetrol/pharmacologyEstradiol/analogs & derivatives/pharmacologyFemaleOvariectomyRatsRats, Wistarbeta-Endorphin/metabolism
Identifiers
PMID: 25595451
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Article (Published version) (1.7 MB) - document accessible for UNIGE members only Limited access to UNIGE
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Research group Groupe Petignat Patrick (933)
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(ISO format)
PLUCHINO, Nicola et al. Effect of estetrol on Beta-Endorphin level in female rats. In: Steroids, 2015, vol. 95, p. 104-110. https://archive-ouverte.unige.ch/unige:89553

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Deposited on : 2016-11-30

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