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Title

Effect of estetrol on Beta-Endorphin level in female rats
Authors
Pluchino, Nicola
Drakopoulos, Panagiotis
Casarosa, E
Freschi, L
Petignat, Patrick
Yaron, Michal
Genazzani, A R
Published in Steroids. 2015, vol. 95, p. 104-110
Abstract Estetrol (E4), a naturally occurring estrogen produced exclusively by human fetal liver, is currently being evaluated for potential use in contraception and menopausal care in humans. The present study was designed to profile E4 effects on the central nervous system, to assess the in vivo effects of E4 administration on Beta-Endorphin (β-END) release in specific brain structures and to evaluate whether E4 has synergic or antagonistic effects on estradiol-mediated β-END synthesis.
Keywords Animals — Dose-Response Relationship, Drug — Drug Antagonism — Drug Synergism — Estetrol/pharmacology — Estradiol/analogs & derivatives/pharmacology — Female — Ovariectomy — Rats — Rats, Wistar — beta-Endorphin/metabolism
Identifiers
PMID: 25595451
Full text
Article (Published version) (1.7 MB) - document accessible for UNIGE members only Limited access to UNIGE
Structures
Faculté de médecine / Section de médecine clinique / Département de pédiatrie, gynécologie et obstétrique
Research group Prévention du cancer du col utérin (933)
Citation
(ISO format) 		PLUCHINO, Nicola et al. Effect of estetrol on Beta-Endorphin level in female rats. In: Steroids, 2015, vol. 95, p. 104-110. doi: 10.1016/j.steroids.2015.01.003 https://archive-ouverte.unige.ch/unige:89553

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Deposited on : 2016-11-30

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