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Effect of estetrol on Beta-Endorphin level in female rats

Casarosa, E
Freschi, L
Genazzani, A R
Published in Steroids. 2015, vol. 95, p. 104-110
Abstract Estetrol (E4), a naturally occurring estrogen produced exclusively by human fetal liver, is currently being evaluated for potential use in contraception and menopausal care in humans. The present study was designed to profile E4 effects on the central nervous system, to assess the in vivo effects of E4 administration on Beta-Endorphin (β-END) release in specific brain structures and to evaluate whether E4 has synergic or antagonistic effects on estradiol-mediated β-END synthesis.
Keywords AnimalsDose-Response Relationship, DrugDrug AntagonismDrug SynergismEstetrol/pharmacologyEstradiol/analogs & derivatives/pharmacologyFemaleOvariectomyRatsRats, Wistarbeta-Endorphin/metabolism
PMID: 25595451
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Research group Prévention du cancer du col utérin (933)
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PLUCHINO, Nicola et al. Effect of estetrol on Beta-Endorphin level in female rats. In: Steroids, 2015, vol. 95, p. 104-110. doi: 10.1016/j.steroids.2015.01.003 https://archive-ouverte.unige.ch/unige:89553

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Deposited on : 2016-11-30

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