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Small molecules as tool compounds to probe Target of Rapamycin (TOR) signaling

Defense Thèse de doctorat : Univ. Genève, 2016 - Sc. 4974 - 2016/08/29
Abstract The development of tool compounds to interrogate TOR signaling greatly facilitates our understanding of the complex and multilayered pathways governing TOR. In this study, we present two new molecules that can be used to decipher both upstream and direct TOR regulation. We have shown that the use of palmitoylcarnitine can guide insights into new models for TORC2 inhibition, an area that is fundamentally challenging to interrogate with the current TOR toolbox repetoire. CMB5806 shows great promise as a novel class of TOR inhibitors and its use as an activity based probe will allow us to determine the active state of the TOR kinase in variable conditions. In conclusion, two valuable tool compounds are developed in this study and will assist future understanding of TOR signaling.
URN: urn:nbn:ch:unige-894967
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Research group Groupe Loewith
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NIEWOLA-STASZKOWSKA, Karolina. Small molecules as tool compounds to probe Target of Rapamycin (TOR) signaling. Université de Genève. Thèse, 2016. doi: 10.13097/archive-ouverte/unige:89496 https://archive-ouverte.unige.ch/unige:89496

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Deposited on : 2016-11-28

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